HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1

m6Am is a modification of the 5′ end of mRNAs catalyzed by PCIF1. Here, Zhang et al. show that HIV infection induces a decrease in m6Am of cellular mRNAs through Vpr-mediated PCIF1 ubiquitination and degradation, resulting in increased HIV replication through regulation of host transcription factors...

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Auteurs principaux:	Qiong Zhang, Yuqi Kang, Shaobo Wang, Gwendolyn Michelle Gonzalez, Wanyu Li, Hui Hui, Yinsheng Wang, Tariq M. Rana
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/fb56db68233044dbb072c21342e30cd3
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spelling	oai:doaj.org-article:fb56db68233044dbb072c21342e30cd32021-12-02T15:14:56ZHIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF110.1038/s41467-021-25683-42041-1723https://doaj.org/article/fb56db68233044dbb072c21342e30cd32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25683-4https://doaj.org/toc/2041-1723m6Am is a modification of the 5′ end of mRNAs catalyzed by PCIF1. Here, Zhang et al. show that HIV infection induces a decrease in m6Am of cellular mRNAs through Vpr-mediated PCIF1 ubiquitination and degradation, resulting in increased HIV replication through regulation of host transcription factors.Qiong ZhangYuqi KangShaobo WangGwendolyn Michelle GonzalezWanyu LiHui HuiYinsheng WangTariq M. RanaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiong Zhang Yuqi Kang Shaobo Wang Gwendolyn Michelle Gonzalez Wanyu Li Hui Hui Yinsheng Wang Tariq M. Rana HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1
description	m6Am is a modification of the 5′ end of mRNAs catalyzed by PCIF1. Here, Zhang et al. show that HIV infection induces a decrease in m6Am of cellular mRNAs through Vpr-mediated PCIF1 ubiquitination and degradation, resulting in increased HIV replication through regulation of host transcription factors.
format	article
author	Qiong Zhang Yuqi Kang Shaobo Wang Gwendolyn Michelle Gonzalez Wanyu Li Hui Hui Yinsheng Wang Tariq M. Rana
author_facet	Qiong Zhang Yuqi Kang Shaobo Wang Gwendolyn Michelle Gonzalez Wanyu Li Hui Hui Yinsheng Wang Tariq M. Rana
author_sort	Qiong Zhang
title	HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1
title_short	HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1
title_full	HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1
title_fullStr	HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1
title_full_unstemmed	HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1
title_sort	hiv reprograms host m6am rna methylome by viral vpr protein-mediated degradation of pcif1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb56db68233044dbb072c21342e30cd3
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HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1

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