HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1

m6Am is a modification of the 5′ end of mRNAs catalyzed by PCIF1. Here, Zhang et al. show that HIV infection induces a decrease in m6Am of cellular mRNAs through Vpr-mediated PCIF1 ubiquitination and degradation, resulting in increased HIV replication through regulation of host transcription factors...

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Autores principales: Qiong Zhang, Yuqi Kang, Shaobo Wang, Gwendolyn Michelle Gonzalez, Wanyu Li, Hui Hui, Yinsheng Wang, Tariq M. Rana
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fb56db68233044dbb072c21342e30cd3
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