Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy

Autophagic cells coordinate substrate remodeling with sequestration during autophagosome formation. Here, the authors show that during Parkin-mediated mitophagy, mitochondria are disassembled into progressively smaller aggregates near autophagy initiation sites in a PtdIns(4,5)P2-dependent manner.

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Autores principales:	Cheng-Wei Hsieh, Wei Yuan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb5ab33492a34b27a856b6d22e6669ef
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spelling	oai:doaj.org-article:fb5ab33492a34b27a856b6d22e6669ef2021-12-02T16:57:09ZOmegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy10.1038/s41467-019-08924-52041-1723https://doaj.org/article/fb5ab33492a34b27a856b6d22e6669ef2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08924-5https://doaj.org/toc/2041-1723Autophagic cells coordinate substrate remodeling with sequestration during autophagosome formation. Here, the authors show that during Parkin-mediated mitophagy, mitochondria are disassembled into progressively smaller aggregates near autophagy initiation sites in a PtdIns(4,5)P2-dependent manner.Cheng-Wei HsiehWei Yuan YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng-Wei Hsieh Wei Yuan Yang Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
description	Autophagic cells coordinate substrate remodeling with sequestration during autophagosome formation. Here, the authors show that during Parkin-mediated mitophagy, mitochondria are disassembled into progressively smaller aggregates near autophagy initiation sites in a PtdIns(4,5)P2-dependent manner.
format	article
author	Cheng-Wei Hsieh Wei Yuan Yang
author_facet	Cheng-Wei Hsieh Wei Yuan Yang
author_sort	Cheng-Wei Hsieh
title	Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
title_short	Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
title_full	Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
title_fullStr	Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
title_full_unstemmed	Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
title_sort	omegasome-proximal ptdins(4,5)p2 couples f-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fb5ab33492a34b27a856b6d22e6669ef
work_keys_str_mv	AT chengweihsieh omegasomeproximalptdins45p2couplesfactinmediatedmitoaggregatedisassemblywithautophagosomeformationduringmitophagy AT weiyuanyang omegasomeproximalptdins45p2couplesfactinmediatedmitoaggregatedisassemblywithautophagosomeformationduringmitophagy
_version_	1718382659822944256

Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy

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