The complexity of tumour angiogenesis based on recently described molecules

Tumour angiogenesis is a crucial factor associated with tumour growth, progression, and metastasis. The whole process is the result of an interaction between a wide range of different molecules, influencing each other. Herein we summarize novel discoveries related to the less known angiogenic molecu...

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Autores principales:	Weronika Wiśniewska, Michal Kopka, Karolina Siemiątkowska, Marta Magdalena Fudalej, Aleksandra Sobiborowicz, Anna Maria Badowska-Kozakiewicz
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2021
Materias:	angiogenesis carcinogenesis galectins. Medicine R
Acceso en línea:	https://doaj.org/article/fb5d96a30e414c1ebf73fe7a07270415
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spelling	oai:doaj.org-article:fb5d96a30e414c1ebf73fe7a072704152021-12-02T19:19:15ZThe complexity of tumour angiogenesis based on recently described molecules1428-25261897-430910.5114/wo.2021.105075https://doaj.org/article/fb5d96a30e414c1ebf73fe7a072704152021-04-01T00:00:00Zhttps://www.termedia.pl/The-complexity-of-tumour-angiogenesis-based-on-recently-described-molecules,3,43728,1,1.htmlhttps://doaj.org/toc/1428-2526https://doaj.org/toc/1897-4309Tumour angiogenesis is a crucial factor associated with tumour growth, progression, and metastasis. The whole process is the result of an interaction between a wide range of different molecules, influencing each other. Herein we summarize novel discoveries related to the less known angiogenic molecules such as galectins, pentraxin-3, Ral-interacting protein of 76 kDa (RLIP76), long non-coding RNAs (lncRNAs), B7-H3, and delta-like ligand-4 (DLL-4) and their role in the process of tumour angiogenesis. These molecules influence the most important molecular pathways involved in the formation of blood vessels in cancer, including the vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor interaction (VEGFR), HIF1-a activation, or PI3K/Akt/mTOR and JAK-STAT signalling pathways. Increased expression of galectins, RLIP76, and B7H3 has been proven in several malignancies. Pentraxin-3, which appears to inhibit tumour angiogenesis, shows reduced expression in tumour tissues. Anti-angiogenic treatment based mainly on VEGF inhibition has proved to be of limited effectiveness, leading to the development of drug resistance. The newly discovered molecules are of great interest as a potential source of new anti-cancer therapies. Their role as targets for new drugs and as prognostic markers in neoplasms is discussed in this review.Weronika WiśniewskaMichal KopkaKarolina SiemiątkowskaMarta Magdalena FudalejAleksandra SobiborowiczAnna Maria Badowska-KozakiewiczTermedia Publishing Housearticleangiogenesis carcinogenesis galectins.MedicineRENContemporary Oncology, Vol 25, Iss 1, Pp 33-44 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiogenesis carcinogenesis galectins. Medicine R
spellingShingle	angiogenesis carcinogenesis galectins. Medicine R Weronika Wiśniewska Michal Kopka Karolina Siemiątkowska Marta Magdalena Fudalej Aleksandra Sobiborowicz Anna Maria Badowska-Kozakiewicz The complexity of tumour angiogenesis based on recently described molecules
description	Tumour angiogenesis is a crucial factor associated with tumour growth, progression, and metastasis. The whole process is the result of an interaction between a wide range of different molecules, influencing each other. Herein we summarize novel discoveries related to the less known angiogenic molecules such as galectins, pentraxin-3, Ral-interacting protein of 76 kDa (RLIP76), long non-coding RNAs (lncRNAs), B7-H3, and delta-like ligand-4 (DLL-4) and their role in the process of tumour angiogenesis. These molecules influence the most important molecular pathways involved in the formation of blood vessels in cancer, including the vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor interaction (VEGFR), HIF1-a activation, or PI3K/Akt/mTOR and JAK-STAT signalling pathways. Increased expression of galectins, RLIP76, and B7H3 has been proven in several malignancies. Pentraxin-3, which appears to inhibit tumour angiogenesis, shows reduced expression in tumour tissues. Anti-angiogenic treatment based mainly on VEGF inhibition has proved to be of limited effectiveness, leading to the development of drug resistance. The newly discovered molecules are of great interest as a potential source of new anti-cancer therapies. Their role as targets for new drugs and as prognostic markers in neoplasms is discussed in this review.
format	article
author	Weronika Wiśniewska Michal Kopka Karolina Siemiątkowska Marta Magdalena Fudalej Aleksandra Sobiborowicz Anna Maria Badowska-Kozakiewicz
author_facet	Weronika Wiśniewska Michal Kopka Karolina Siemiątkowska Marta Magdalena Fudalej Aleksandra Sobiborowicz Anna Maria Badowska-Kozakiewicz
author_sort	Weronika Wiśniewska
title	The complexity of tumour angiogenesis based on recently described molecules
title_short	The complexity of tumour angiogenesis based on recently described molecules
title_full	The complexity of tumour angiogenesis based on recently described molecules
title_fullStr	The complexity of tumour angiogenesis based on recently described molecules
title_full_unstemmed	The complexity of tumour angiogenesis based on recently described molecules
title_sort	complexity of tumour angiogenesis based on recently described molecules
publisher	Termedia Publishing House
publishDate	2021
url	https://doaj.org/article/fb5d96a30e414c1ebf73fe7a07270415
work_keys_str_mv	AT weronikawisniewska thecomplexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT michalkopka thecomplexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT karolinasiemiatkowska thecomplexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT martamagdalenafudalej thecomplexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT aleksandrasobiborowicz thecomplexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT annamariabadowskakozakiewicz thecomplexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT weronikawisniewska complexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT michalkopka complexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT karolinasiemiatkowska complexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT martamagdalenafudalej complexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT aleksandrasobiborowicz complexityoftumourangiogenesisbasedonrecentlydescribedmolecules AT annamariabadowskakozakiewicz complexityoftumourangiogenesisbasedonrecentlydescribedmolecules
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The complexity of tumour angiogenesis based on recently described molecules

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