Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

Background: We aimed to establish an acute treatment protocol to increase serum vitamin D, evaluate the effectiveness of vitamin D3 supplementation, and reveal the potential mechanisms in COVID-19. Methods: We retrospectively analyzed the data of 867 COVID-19 cases. Then, a prospective study was con...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mustafa Sait Gönen, Merve Alaylıoğlu, Emre Durcan, Yusuf Özdemir, Serdar Şahin, Dildar Konukoğlu, Okan Kadir Nohut, Seval Ürkmez, Berna Küçükece, İlker İnanç Balkan, H. Volkan Kara, Şermin Börekçi, Hande Özkaya, Zekayi Kutlubay, Yalım Dikmen, Yılmaz Keskindemirci, Spyridon N. Karras, Cedric Annweiler, Duygu Gezen-Ak, Erdinç Dursun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 vitamin D cytokine cathelicidin-LL37 acute respiratory failure Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/fb5f9c30585348a2ad4b4e547856908e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fb5f9c30585348a2ad4b4e547856908e
record_format	dspace
spelling	oai:doaj.org-article:fb5f9c30585348a2ad4b4e547856908e2021-11-25T18:36:25ZRapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM110.3390/nu131140472072-6643https://doaj.org/article/fb5f9c30585348a2ad4b4e547856908e2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4047https://doaj.org/toc/2072-6643Background: We aimed to establish an acute treatment protocol to increase serum vitamin D, evaluate the effectiveness of vitamin D3 supplementation, and reveal the potential mechanisms in COVID-19. Methods: We retrospectively analyzed the data of 867 COVID-19 cases. Then, a prospective study was conducted, including 23 healthy individuals and 210 cases. A total of 163 cases had vitamin D supplementation, and 95 were followed for 14 days. Clinical outcomes, routine blood biomarkers, serum levels of vitamin D metabolism, and action mechanism-related parameters were evaluated. Results: Our treatment protocol increased the serum 25OHD levels significantly to above 30 ng/mL within two weeks. COVID-19 cases (no comorbidities, no vitamin D treatment, 25OHD <30 ng/mL) had 1.9-fold increased risk of having hospitalization longer than 8 days compared with the cases with comorbidities and vitamin D treatment. Having vitamin D treatment decreased the mortality rate by 2.14 times. The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Conclusions: Vitamin D treatment shortened hospital stay and decreased mortality in COVID-19 cases, even in the existence of comorbidities. Vitamin D supplementation is effective on various target parameters; therefore, it is essential for COVID-19 treatment.Mustafa Sait GönenMerve AlaylıoğluEmre DurcanYusuf ÖzdemirSerdar ŞahinDildar KonukoğluOkan Kadir NohutSeval ÜrkmezBerna Küçükeceİlker İnanç BalkanH. Volkan KaraŞermin BörekçiHande ÖzkayaZekayi KutlubayYalım DikmenYılmaz KeskindemirciSpyridon N. KarrasCedric AnnweilerDuygu Gezen-AkErdinç DursunMDPI AGarticleSARS-CoV-2COVID-19vitamin Dcytokinecathelicidin-LL37acute respiratory failureNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4047, p 4047 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 vitamin D cytokine cathelicidin-LL37 acute respiratory failure Nutrition. Foods and food supply TX341-641
spellingShingle	SARS-CoV-2 COVID-19 vitamin D cytokine cathelicidin-LL37 acute respiratory failure Nutrition. Foods and food supply TX341-641 Mustafa Sait Gönen Merve Alaylıoğlu Emre Durcan Yusuf Özdemir Serdar Şahin Dildar Konukoğlu Okan Kadir Nohut Seval Ürkmez Berna Küçükece İlker İnanç Balkan H. Volkan Kara Şermin Börekçi Hande Özkaya Zekayi Kutlubay Yalım Dikmen Yılmaz Keskindemirci Spyridon N. Karras Cedric Annweiler Duygu Gezen-Ak Erdinç Dursun Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1
description	Background: We aimed to establish an acute treatment protocol to increase serum vitamin D, evaluate the effectiveness of vitamin D3 supplementation, and reveal the potential mechanisms in COVID-19. Methods: We retrospectively analyzed the data of 867 COVID-19 cases. Then, a prospective study was conducted, including 23 healthy individuals and 210 cases. A total of 163 cases had vitamin D supplementation, and 95 were followed for 14 days. Clinical outcomes, routine blood biomarkers, serum levels of vitamin D metabolism, and action mechanism-related parameters were evaluated. Results: Our treatment protocol increased the serum 25OHD levels significantly to above 30 ng/mL within two weeks. COVID-19 cases (no comorbidities, no vitamin D treatment, 25OHD <30 ng/mL) had 1.9-fold increased risk of having hospitalization longer than 8 days compared with the cases with comorbidities and vitamin D treatment. Having vitamin D treatment decreased the mortality rate by 2.14 times. The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Conclusions: Vitamin D treatment shortened hospital stay and decreased mortality in COVID-19 cases, even in the existence of comorbidities. Vitamin D supplementation is effective on various target parameters; therefore, it is essential for COVID-19 treatment.
format	article
author	Mustafa Sait Gönen Merve Alaylıoğlu Emre Durcan Yusuf Özdemir Serdar Şahin Dildar Konukoğlu Okan Kadir Nohut Seval Ürkmez Berna Küçükece İlker İnanç Balkan H. Volkan Kara Şermin Börekçi Hande Özkaya Zekayi Kutlubay Yalım Dikmen Yılmaz Keskindemirci Spyridon N. Karras Cedric Annweiler Duygu Gezen-Ak Erdinç Dursun
author_facet	Mustafa Sait Gönen Merve Alaylıoğlu Emre Durcan Yusuf Özdemir Serdar Şahin Dildar Konukoğlu Okan Kadir Nohut Seval Ürkmez Berna Küçükece İlker İnanç Balkan H. Volkan Kara Şermin Börekçi Hande Özkaya Zekayi Kutlubay Yalım Dikmen Yılmaz Keskindemirci Spyridon N. Karras Cedric Annweiler Duygu Gezen-Ak Erdinç Dursun
author_sort	Mustafa Sait Gönen
title	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1
title_short	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1
title_full	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1
title_fullStr	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1
title_full_unstemmed	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1
title_sort	rapid and effective vitamin d supplementation may present better clinical outcomes in covid-19 (sars-cov-2) patients by altering serum inos1, il1b, ifng, cathelicidin-ll37, and icam1
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fb5f9c30585348a2ad4b4e547856908e
work_keys_str_mv	AT mustafasaitgonen rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT mervealaylıoglu rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT emredurcan rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT yusufozdemir rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT serdarsahin rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT dildarkonukoglu rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT okankadirnohut rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT sevalurkmez rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT bernakucukece rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT ilkerinancbalkan rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT hvolkankara rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT serminborekci rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT handeozkaya rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT zekayikutlubay rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT yalımdikmen rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT yılmazkeskindemirci rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT spyridonnkarras rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT cedricannweiler rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT duygugezenak rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1 AT erdincdursun rapidandeffectivevitamindsupplementationmaypresentbetterclinicaloutcomesincovid19sarscov2patientsbyalteringseruminos1il1bifngcathelicidinll37andicam1
_version_	1718410931971555328

Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

Ejemplares similares