Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)

Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite, has been implicated as a novel risk factor for cardiovascular events related to obesity and type 2 diabetes mellitus (T2DM). The aim of the study was to test the hypothesis if TMAO is associated with the reduction of cardiovascular d...

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Autores principales:	Soo Jin Lee, Young Suk Park, Yong-Jin Kim, Sang-Uk Han, Geum-Sook Hwang, Yeyoung Han, Yoonseok Heo, Eunyoung Ha, Tae Kyung Ha
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	trimethylamine N-oxide cardiovascular disease obesity bariatric surgery diabetes mellitus Medicine R
Acceso en línea:	https://doaj.org/article/fb612042ed6940f097c626a1a52a5ef2
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spelling	oai:doaj.org-article:fb612042ed6940f097c626a1a52a5ef22021-11-11T17:42:44ZChanges in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)10.3390/jcm102150912077-0383https://doaj.org/article/fb612042ed6940f097c626a1a52a5ef22021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5091https://doaj.org/toc/2077-0383Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite, has been implicated as a novel risk factor for cardiovascular events related to obesity and type 2 diabetes mellitus (T2DM). The aim of the study was to test the hypothesis if TMAO is associated with the reduction of cardiovascular disease in the Korean obese patients who underwent bariatric surgery. From a subgroup of a multicenter, nonrandomized, controlled trial, titled KOBESS, 38 obese patients, 18 with and 20 without T2DM, who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were investigated. Bariatric surgery is indicated for Korean patients with a body mass index (BMI) ≥ 35 kg/m<sup>2</sup> or for Korean patients with a BMI ≥ 30 kg/m<sup>2</sup> who have comorbidities. Serum levels of TMAO and its precursors, betaine, carnitine, and choline were measured before and six months after bariatric surgery. The levels of TMAO and its precursors did not differ between obese patients with T2DM and non-T2DM at baseline. However, TMAO increased more than twofold in patients with T2DM after RYGB surgery, but not in patients without T2DM. Choline levels were decreased by half in all patients after RYGB. In patients with T2DM who underwent SG, TMAO, betaine, and carnitine levels did not change after the surgery. Furthermore, in obese patients who underwent bariatric surgery, increased TMAO levels were associated with both T2DM and RYGB, while reduced choline levels were associated with RYGB. These associations need to be further elucidated in follow-up studies to gain further insights into the relationship between TMAO levels and bariatric surgery outcomes.Soo Jin LeeYoung Suk ParkYong-Jin KimSang-Uk HanGeum-Sook HwangYeyoung HanYoonseok HeoEunyoung HaTae Kyung HaMDPI AGarticletrimethylamine N-oxidecardiovascular diseaseobesitybariatric surgerydiabetes mellitusMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5091, p 5091 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	trimethylamine N-oxide cardiovascular disease obesity bariatric surgery diabetes mellitus Medicine R
spellingShingle	trimethylamine N-oxide cardiovascular disease obesity bariatric surgery diabetes mellitus Medicine R Soo Jin Lee Young Suk Park Yong-Jin Kim Sang-Uk Han Geum-Sook Hwang Yeyoung Han Yoonseok Heo Eunyoung Ha Tae Kyung Ha Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)
description	Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite, has been implicated as a novel risk factor for cardiovascular events related to obesity and type 2 diabetes mellitus (T2DM). The aim of the study was to test the hypothesis if TMAO is associated with the reduction of cardiovascular disease in the Korean obese patients who underwent bariatric surgery. From a subgroup of a multicenter, nonrandomized, controlled trial, titled KOBESS, 38 obese patients, 18 with and 20 without T2DM, who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were investigated. Bariatric surgery is indicated for Korean patients with a body mass index (BMI) ≥ 35 kg/m<sup>2</sup> or for Korean patients with a BMI ≥ 30 kg/m<sup>2</sup> who have comorbidities. Serum levels of TMAO and its precursors, betaine, carnitine, and choline were measured before and six months after bariatric surgery. The levels of TMAO and its precursors did not differ between obese patients with T2DM and non-T2DM at baseline. However, TMAO increased more than twofold in patients with T2DM after RYGB surgery, but not in patients without T2DM. Choline levels were decreased by half in all patients after RYGB. In patients with T2DM who underwent SG, TMAO, betaine, and carnitine levels did not change after the surgery. Furthermore, in obese patients who underwent bariatric surgery, increased TMAO levels were associated with both T2DM and RYGB, while reduced choline levels were associated with RYGB. These associations need to be further elucidated in follow-up studies to gain further insights into the relationship between TMAO levels and bariatric surgery outcomes.
format	article
author	Soo Jin Lee Young Suk Park Yong-Jin Kim Sang-Uk Han Geum-Sook Hwang Yeyoung Han Yoonseok Heo Eunyoung Ha Tae Kyung Ha
author_facet	Soo Jin Lee Young Suk Park Yong-Jin Kim Sang-Uk Han Geum-Sook Hwang Yeyoung Han Yoonseok Heo Eunyoung Ha Tae Kyung Ha
author_sort	Soo Jin Lee
title	Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)
title_short	Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)
title_full	Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)
title_fullStr	Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)
title_full_unstemmed	Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)
title_sort	changes in trimethylamine-n-oxide levels in obese patients following laparoscopic roux-en-y gastric bypass or sleeve gastrectomy in a korean obesity surgical treatment study (kobess)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fb612042ed6940f097c626a1a52a5ef2
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Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)

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