c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats

Abstract Deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BST), a region implicated in the expression of anxiety, shows promise in psychiatric patients, but its effects throughout the limbic system are largely unknown. In male Wistar rats, we first evaluated the neural signat...

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Autores principales:	Kelly Luyck, Isabelle Scheyltjens, Bart Nuttin, Lutgarde Arckens, Laura Luyten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb623ef573a74c45bca016fc7655fe0e
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spelling	oai:doaj.org-article:fb623ef573a74c45bca016fc7655fe0e2021-12-02T12:33:46Zc-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats10.1038/s41598-020-77603-z2045-2322https://doaj.org/article/fb623ef573a74c45bca016fc7655fe0e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77603-zhttps://doaj.org/toc/2045-2322Abstract Deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BST), a region implicated in the expression of anxiety, shows promise in psychiatric patients, but its effects throughout the limbic system are largely unknown. In male Wistar rats, we first evaluated the neural signature of contextual fear (N = 16) and next, of the anxiolytic effects of high-frequency electrical stimulation in the BST (N = 31), by means of c-Fos protein expression. In non-operated animals, we found that the left medial anterior BST displayed increased c-Fos expression in anxious (i.e., context-conditioned) versus control subjects. Moreover, control rats showed asymmetric expression in the basolateral amygdala (BLA) (i.e., higher intensities in the right hemisphere), which was absent in anxious animals. The predominant finding in rats receiving bilateral BST stimulation was a striking increase in c-Fos expression throughout much of the left hemisphere, which was not confined to the predefined regions of interest. To conclude, we found evidence for lateralized c-Fos expression during the expression of contextual fear and anxiolytic high-frequency electrical stimulation of the BST, particularly in the medial anterior BST and BLA. In addition, we observed an extensive and unexpected left-sided c-Fos spread following bilateral stimulation in the BST.Kelly LuyckIsabelle ScheyltjensBart NuttinLutgarde ArckensLaura LuytenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kelly Luyck Isabelle Scheyltjens Bart Nuttin Lutgarde Arckens Laura Luyten c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats
description	Abstract Deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BST), a region implicated in the expression of anxiety, shows promise in psychiatric patients, but its effects throughout the limbic system are largely unknown. In male Wistar rats, we first evaluated the neural signature of contextual fear (N = 16) and next, of the anxiolytic effects of high-frequency electrical stimulation in the BST (N = 31), by means of c-Fos protein expression. In non-operated animals, we found that the left medial anterior BST displayed increased c-Fos expression in anxious (i.e., context-conditioned) versus control subjects. Moreover, control rats showed asymmetric expression in the basolateral amygdala (BLA) (i.e., higher intensities in the right hemisphere), which was absent in anxious animals. The predominant finding in rats receiving bilateral BST stimulation was a striking increase in c-Fos expression throughout much of the left hemisphere, which was not confined to the predefined regions of interest. To conclude, we found evidence for lateralized c-Fos expression during the expression of contextual fear and anxiolytic high-frequency electrical stimulation of the BST, particularly in the medial anterior BST and BLA. In addition, we observed an extensive and unexpected left-sided c-Fos spread following bilateral stimulation in the BST.
format	article
author	Kelly Luyck Isabelle Scheyltjens Bart Nuttin Lutgarde Arckens Laura Luyten
author_facet	Kelly Luyck Isabelle Scheyltjens Bart Nuttin Lutgarde Arckens Laura Luyten
author_sort	Kelly Luyck
title	c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats
title_short	c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats
title_full	c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats
title_fullStr	c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats
title_full_unstemmed	c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats
title_sort	c-fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fb623ef573a74c45bca016fc7655fe0e
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c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats

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