Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ channels through BAG3

Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ channels through BAG3

Calenduloside E (CE) is a saponin isolated from Aralia elata (Miq) Seem, which has anti-cardiovascular disease effects. This study aims to evaluate the anti-myocardial ischemia-reperfusion injury (MIRI) mechanisms of CE and regulation of BAG3 on calcium overload. We adopted siRNA to interfere with B...

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Autores principales: Ruiying Wang, Min Wang, Bo Liu, Huibo Xu, Jingxue Ye, Xiaobo Sun, Guibo Sun
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
calenduloside E
myocardial ischemia-reperfusion injury
L-type Ca2+ channels
BAG3
calcium overload
autophagy
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/fb63903b138c44a08284f0c48e477f8c
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