hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state

hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state

Abstract Delayed-rectifier potassium channels (hERG and KCNQ1) play a major role in cardiac repolarization. These channels are formed by a tetrameric pore (S5–S6) surrounded by four voltage sensor domains (S1-S4). Coupling between voltage sensor domains and the pore activation gate is critical for c...

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Autores principales: Olfat A. Malak, Zeineb Es-Salah-Lamoureux, Gildas Loussouarn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/fb63c05f0749402ab82a3705894795ad
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