The effects of bathing in neutral bicarbonate ion water

Abstract Percutaneously absorbed carbon dioxide enhances blood flow. The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow v...

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Autores principales:	Tomoe Yamazaki, Ryoko Ushikoshi-Nakayama, Supriya Shakya, Daisuke Omagari, Naoyuki Matsumoto, Chiyoko Nukuzuma, Tomoko Komatsu, Masaichi Chang-il Lee, Hiroko Inoue, Ichiro Saito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb6488ead01f4fe9a1ada708f739bf80
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spelling	oai:doaj.org-article:fb6488ead01f4fe9a1ada708f739bf802021-11-14T12:21:04ZThe effects of bathing in neutral bicarbonate ion water10.1038/s41598-021-01285-42045-2322https://doaj.org/article/fb6488ead01f4fe9a1ada708f739bf802021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01285-4https://doaj.org/toc/2045-2322Abstract Percutaneously absorbed carbon dioxide enhances blood flow. The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow via phosphorylation of peripheral vascular endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO). Phosphorylation of eNOS and NO production were also increased in human umbilical vein endothelial cells cultured in medium containing NBIW, and NBIW showed reactive oxygen species scavenging activity. In a double-blind, randomized study in men and women aged 30 to 59 years with subjective cold intolerance, bathing in NBIW elevated body temperature faster than bathing in a control solution and improved chills and sleep quality. Taken together, our results show that percutaneously absorbed carbon dioxide changes to bicarbonate ions, which act directly on endothelial cells to increase NO production by phosphorylation of eNOS and thus improve blood flow.Tomoe YamazakiRyoko Ushikoshi-NakayamaSupriya ShakyaDaisuke OmagariNaoyuki MatsumotoChiyoko NukuzumaTomoko KomatsuMasaichi Chang-il LeeHiroko InoueIchiro SaitoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoe Yamazaki Ryoko Ushikoshi-Nakayama Supriya Shakya Daisuke Omagari Naoyuki Matsumoto Chiyoko Nukuzuma Tomoko Komatsu Masaichi Chang-il Lee Hiroko Inoue Ichiro Saito The effects of bathing in neutral bicarbonate ion water
description	Abstract Percutaneously absorbed carbon dioxide enhances blood flow. The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow via phosphorylation of peripheral vascular endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO). Phosphorylation of eNOS and NO production were also increased in human umbilical vein endothelial cells cultured in medium containing NBIW, and NBIW showed reactive oxygen species scavenging activity. In a double-blind, randomized study in men and women aged 30 to 59 years with subjective cold intolerance, bathing in NBIW elevated body temperature faster than bathing in a control solution and improved chills and sleep quality. Taken together, our results show that percutaneously absorbed carbon dioxide changes to bicarbonate ions, which act directly on endothelial cells to increase NO production by phosphorylation of eNOS and thus improve blood flow.
format	article
author	Tomoe Yamazaki Ryoko Ushikoshi-Nakayama Supriya Shakya Daisuke Omagari Naoyuki Matsumoto Chiyoko Nukuzuma Tomoko Komatsu Masaichi Chang-il Lee Hiroko Inoue Ichiro Saito
author_facet	Tomoe Yamazaki Ryoko Ushikoshi-Nakayama Supriya Shakya Daisuke Omagari Naoyuki Matsumoto Chiyoko Nukuzuma Tomoko Komatsu Masaichi Chang-il Lee Hiroko Inoue Ichiro Saito
author_sort	Tomoe Yamazaki
title	The effects of bathing in neutral bicarbonate ion water
title_short	The effects of bathing in neutral bicarbonate ion water
title_full	The effects of bathing in neutral bicarbonate ion water
title_fullStr	The effects of bathing in neutral bicarbonate ion water
title_full_unstemmed	The effects of bathing in neutral bicarbonate ion water
title_sort	effects of bathing in neutral bicarbonate ion water
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb6488ead01f4fe9a1ada708f739bf80
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The effects of bathing in neutral bicarbonate ion water

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