A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.

<h4>Background</h4>Platelet component (PC) transfusion leads occasionally to inflammatory hazards. Certain BRMs that are secreted by the platelets themselves during storage may have some responsibility.<h4>Methodology/principal findings</h4>First, we identified non-stochastic...

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Autores principales:	Kim Anh Nguyen, Hind Hamzeh-Cognasse, Marc Sebban, Elisa Fromont, Patricia Chavarin, Lena Absi, Bruno Pozzetto, Fabrice Cognasse, Olivier Garraud
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb6b5e82d0c04c41aa24662d3d135332
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spelling	oai:doaj.org-article:fb6b5e82d0c04c41aa24662d3d1353322021-12-02T20:15:56ZA computerized prediction model of hazardous inflammatory platelet transfusion outcomes.1932-620310.1371/journal.pone.0097082https://doaj.org/article/fb6b5e82d0c04c41aa24662d3d1353322014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24830754/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Platelet component (PC) transfusion leads occasionally to inflammatory hazards. Certain BRMs that are secreted by the platelets themselves during storage may have some responsibility.<h4>Methodology/principal findings</h4>First, we identified non-stochastic arrangements of platelet-secreted BRMs in platelet components that led to acute transfusion reactions (ATRs). These data provide formal clinical evidence that platelets generate secretion profiles under both sterile activation and pathological conditions. We next aimed to predict the risk of hazardous outcomes by establishing statistical models based on the associations of BRMs within the incriminated platelet components and using decision trees. We investigated a large (n = 65) series of ATRs after platelet component transfusions reported through a very homogenous system at one university hospital. Herein, we used a combination of clinical observations, ex vivo and in vitro investigations, and mathematical modeling systems. We calculated the statistical association of a large variety (n = 17) of cytokines, chemokines, and physiologically likely factors with acute inflammatory potential in patients presenting with severe hazards. We then generated an accident prediction model that proved to be dependent on the level (amount) of a given cytokine-like platelet product within the indicated component, e.g., soluble CD40-ligand (>289.5 pg/109 platelets), or the presence of another secreted factor (IL-13, >0). We further modeled the risk of the patient presenting either a febrile non-hemolytic transfusion reaction or an atypical allergic transfusion reaction, depending on the amount of the chemokine MIP-1α (<20.4 or >20.4 pg/109 platelets, respectively).<h4>Conclusions/significance</h4>This allows the modeling of a policy of risk prevention for severe inflammatory outcomes in PC transfusion.Kim Anh NguyenHind Hamzeh-CognasseMarc SebbanElisa FromontPatricia ChavarinLena AbsiBruno PozzettoFabrice CognasseOlivier GarraudPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97082 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kim Anh Nguyen Hind Hamzeh-Cognasse Marc Sebban Elisa Fromont Patricia Chavarin Lena Absi Bruno Pozzetto Fabrice Cognasse Olivier Garraud A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.
description	<h4>Background</h4>Platelet component (PC) transfusion leads occasionally to inflammatory hazards. Certain BRMs that are secreted by the platelets themselves during storage may have some responsibility.<h4>Methodology/principal findings</h4>First, we identified non-stochastic arrangements of platelet-secreted BRMs in platelet components that led to acute transfusion reactions (ATRs). These data provide formal clinical evidence that platelets generate secretion profiles under both sterile activation and pathological conditions. We next aimed to predict the risk of hazardous outcomes by establishing statistical models based on the associations of BRMs within the incriminated platelet components and using decision trees. We investigated a large (n = 65) series of ATRs after platelet component transfusions reported through a very homogenous system at one university hospital. Herein, we used a combination of clinical observations, ex vivo and in vitro investigations, and mathematical modeling systems. We calculated the statistical association of a large variety (n = 17) of cytokines, chemokines, and physiologically likely factors with acute inflammatory potential in patients presenting with severe hazards. We then generated an accident prediction model that proved to be dependent on the level (amount) of a given cytokine-like platelet product within the indicated component, e.g., soluble CD40-ligand (>289.5 pg/109 platelets), or the presence of another secreted factor (IL-13, >0). We further modeled the risk of the patient presenting either a febrile non-hemolytic transfusion reaction or an atypical allergic transfusion reaction, depending on the amount of the chemokine MIP-1α (<20.4 or >20.4 pg/109 platelets, respectively).<h4>Conclusions/significance</h4>This allows the modeling of a policy of risk prevention for severe inflammatory outcomes in PC transfusion.
format	article
author	Kim Anh Nguyen Hind Hamzeh-Cognasse Marc Sebban Elisa Fromont Patricia Chavarin Lena Absi Bruno Pozzetto Fabrice Cognasse Olivier Garraud
author_facet	Kim Anh Nguyen Hind Hamzeh-Cognasse Marc Sebban Elisa Fromont Patricia Chavarin Lena Absi Bruno Pozzetto Fabrice Cognasse Olivier Garraud
author_sort	Kim Anh Nguyen
title	A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.
title_short	A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.
title_full	A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.
title_fullStr	A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.
title_full_unstemmed	A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.
title_sort	computerized prediction model of hazardous inflammatory platelet transfusion outcomes.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fb6b5e82d0c04c41aa24662d3d135332
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A computerized prediction model of hazardous inflammatory platelet transfusion outcomes.

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