Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.

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Auteurs principaux:	Guido Pacini, Ilona Dunkel, Norbert Mages, Verena Mutzel, Bernd Timmermann, Annalisa Marsico, Edda G. Schulz
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/fb6c9598aa694328ac2e4a2c1b16bd7b
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spelling	oai:doaj.org-article:fb6c9598aa694328ac2e4a2c1b16bd7b2021-12-02T16:04:29ZIntegrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution10.1038/s41467-021-23643-62041-1723https://doaj.org/article/fb6c9598aa694328ac2e4a2c1b16bd7b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23643-6https://doaj.org/toc/2041-1723X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.Guido PaciniIlona DunkelNorbert MagesVerena MutzelBernd TimmermannAnnalisa MarsicoEdda G. SchulzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guido Pacini Ilona Dunkel Norbert Mages Verena Mutzel Bernd Timmermann Annalisa Marsico Edda G. Schulz Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
description	X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.
format	article
author	Guido Pacini Ilona Dunkel Norbert Mages Verena Mutzel Bernd Timmermann Annalisa Marsico Edda G. Schulz
author_facet	Guido Pacini Ilona Dunkel Norbert Mages Verena Mutzel Bernd Timmermann Annalisa Marsico Edda G. Schulz
author_sort	Guido Pacini
title	Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
title_short	Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
title_full	Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
title_fullStr	Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
title_full_unstemmed	Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
title_sort	integrated analysis of xist upregulation and x-chromosome inactivation with single-cell and single-allele resolution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb6c9598aa694328ac2e4a2c1b16bd7b
work_keys_str_mv	AT guidopacini integratedanalysisofxistupregulationandxchromosomeinactivationwithsinglecellandsinglealleleresolution AT ilonadunkel integratedanalysisofxistupregulationandxchromosomeinactivationwithsinglecellandsinglealleleresolution AT norbertmages integratedanalysisofxistupregulationandxchromosomeinactivationwithsinglecellandsinglealleleresolution AT verenamutzel integratedanalysisofxistupregulationandxchromosomeinactivationwithsinglecellandsinglealleleresolution AT berndtimmermann integratedanalysisofxistupregulationandxchromosomeinactivationwithsinglecellandsinglealleleresolution AT annalisamarsico integratedanalysisofxistupregulationandxchromosomeinactivationwithsinglecellandsinglealleleresolution AT eddagschulz integratedanalysisofxistupregulationandxchromosomeinactivationwithsinglecellandsinglealleleresolution
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Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

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