Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.

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Autores principales: Guido Pacini, Ilona Dunkel, Norbert Mages, Verena Mutzel, Bernd Timmermann, Annalisa Marsico, Edda G. Schulz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/fb6c9598aa694328ac2e4a2c1b16bd7b
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