Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.
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Auteurs principaux: | Guido Pacini, Ilona Dunkel, Norbert Mages, Verena Mutzel, Bernd Timmermann, Annalisa Marsico, Edda G. Schulz |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
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Sujets: | |
Accès en ligne: | https://doaj.org/article/fb6c9598aa694328ac2e4a2c1b16bd7b |
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