Cryo-EM structure of a licensed DNA replication origin

Origins of replication are licensed by loading of MCM onto DNA, and origin firing depends on interaction with Cdc45 and GINS to form two CMG holo-helicases. Here, authors determine the cryo-EM structures of DNA-bound MCM and visualise a phospho-dependent MCM element important for Cdc45 recruitment.

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Autores principales:	Ferdos Abid Ali, Max E. Douglas, Julia Locke, Valerie E. Pye, Andrea Nans, John F. X. Diffley, Alessandro Costa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb70ba000f734f91b445107c7b777e95
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spelling	oai:doaj.org-article:fb70ba000f734f91b445107c7b777e952021-12-02T14:40:45ZCryo-EM structure of a licensed DNA replication origin10.1038/s41467-017-02389-02041-1723https://doaj.org/article/fb70ba000f734f91b445107c7b777e952017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02389-0https://doaj.org/toc/2041-1723Origins of replication are licensed by loading of MCM onto DNA, and origin firing depends on interaction with Cdc45 and GINS to form two CMG holo-helicases. Here, authors determine the cryo-EM structures of DNA-bound MCM and visualise a phospho-dependent MCM element important for Cdc45 recruitment.Ferdos Abid AliMax E. DouglasJulia LockeValerie E. PyeAndrea NansJohn F. X. DiffleyAlessandro CostaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ferdos Abid Ali Max E. Douglas Julia Locke Valerie E. Pye Andrea Nans John F. X. Diffley Alessandro Costa Cryo-EM structure of a licensed DNA replication origin
description	Origins of replication are licensed by loading of MCM onto DNA, and origin firing depends on interaction with Cdc45 and GINS to form two CMG holo-helicases. Here, authors determine the cryo-EM structures of DNA-bound MCM and visualise a phospho-dependent MCM element important for Cdc45 recruitment.
format	article
author	Ferdos Abid Ali Max E. Douglas Julia Locke Valerie E. Pye Andrea Nans John F. X. Diffley Alessandro Costa
author_facet	Ferdos Abid Ali Max E. Douglas Julia Locke Valerie E. Pye Andrea Nans John F. X. Diffley Alessandro Costa
author_sort	Ferdos Abid Ali
title	Cryo-EM structure of a licensed DNA replication origin
title_short	Cryo-EM structure of a licensed DNA replication origin
title_full	Cryo-EM structure of a licensed DNA replication origin
title_fullStr	Cryo-EM structure of a licensed DNA replication origin
title_full_unstemmed	Cryo-EM structure of a licensed DNA replication origin
title_sort	cryo-em structure of a licensed dna replication origin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fb70ba000f734f91b445107c7b777e95
work_keys_str_mv	AT ferdosabidali cryoemstructureofalicenseddnareplicationorigin AT maxedouglas cryoemstructureofalicenseddnareplicationorigin AT julialocke cryoemstructureofalicenseddnareplicationorigin AT valerieepye cryoemstructureofalicenseddnareplicationorigin AT andreanans cryoemstructureofalicenseddnareplicationorigin AT johnfxdiffley cryoemstructureofalicenseddnareplicationorigin AT alessandrocosta cryoemstructureofalicenseddnareplicationorigin
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Cryo-EM structure of a licensed DNA replication origin

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