Impaired learning from regret and disappointment in alcohol use disorder

Abstract The development of alcohol habits is considered a form of maladaptive reinforced learning, with sustained alcohol use resulting in the strengthening of associative links between consumption and either rewarding, or the lack of aversive, experiences. Despite recent efforts in characterizing...

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Autores principales:	Caterina Galandra, Chiara Crespi, Gianpaolo Basso, Nicola Canessa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb72642c74444ec28e2f44163b72ebe4
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spelling	oai:doaj.org-article:fb72642c74444ec28e2f44163b72ebe42021-12-02T16:26:36ZImpaired learning from regret and disappointment in alcohol use disorder10.1038/s41598-020-68942-y2045-2322https://doaj.org/article/fb72642c74444ec28e2f44163b72ebe42020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68942-yhttps://doaj.org/toc/2045-2322Abstract The development of alcohol habits is considered a form of maladaptive reinforced learning, with sustained alcohol use resulting in the strengthening of associative links between consumption and either rewarding, or the lack of aversive, experiences. Despite recent efforts in characterizing decision-making skills in alcohol-use-disorder (AUD), it is still unknown whether impaired behavioural learning in AUD patients reflects a defective processing and anticipation of choice-related, cognitively mediated, emotions such as regret or relief for what might have been under a different choice. We administered a Wheel-of-Fortune (WoF) task to 26 AUD patients and 19 healthy controls, to investigate possible alterations in adjusting choices to the magnitude of experienced regret/relief, and in other facets of decision-making performance such as choice latency. AUD patients displayed both longer deliberation time than healthy controls, and impaired adaptations to previous outcome-related negative emotions. Although further evidence is needed to unveil the cognitive mechanisms underlying AUD patients’ abnormal choice, the present results highlight important implications for the clinical practice, e.g. in terms of cognitive treatments aiming to shape faulty perceptions about negative emotions associated with excessive alcohol exposure.Caterina GalandraChiara CrespiGianpaolo BassoNicola CanessaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caterina Galandra Chiara Crespi Gianpaolo Basso Nicola Canessa Impaired learning from regret and disappointment in alcohol use disorder
description	Abstract The development of alcohol habits is considered a form of maladaptive reinforced learning, with sustained alcohol use resulting in the strengthening of associative links between consumption and either rewarding, or the lack of aversive, experiences. Despite recent efforts in characterizing decision-making skills in alcohol-use-disorder (AUD), it is still unknown whether impaired behavioural learning in AUD patients reflects a defective processing and anticipation of choice-related, cognitively mediated, emotions such as regret or relief for what might have been under a different choice. We administered a Wheel-of-Fortune (WoF) task to 26 AUD patients and 19 healthy controls, to investigate possible alterations in adjusting choices to the magnitude of experienced regret/relief, and in other facets of decision-making performance such as choice latency. AUD patients displayed both longer deliberation time than healthy controls, and impaired adaptations to previous outcome-related negative emotions. Although further evidence is needed to unveil the cognitive mechanisms underlying AUD patients’ abnormal choice, the present results highlight important implications for the clinical practice, e.g. in terms of cognitive treatments aiming to shape faulty perceptions about negative emotions associated with excessive alcohol exposure.
format	article
author	Caterina Galandra Chiara Crespi Gianpaolo Basso Nicola Canessa
author_facet	Caterina Galandra Chiara Crespi Gianpaolo Basso Nicola Canessa
author_sort	Caterina Galandra
title	Impaired learning from regret and disappointment in alcohol use disorder
title_short	Impaired learning from regret and disappointment in alcohol use disorder
title_full	Impaired learning from regret and disappointment in alcohol use disorder
title_fullStr	Impaired learning from regret and disappointment in alcohol use disorder
title_full_unstemmed	Impaired learning from regret and disappointment in alcohol use disorder
title_sort	impaired learning from regret and disappointment in alcohol use disorder
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fb72642c74444ec28e2f44163b72ebe4
work_keys_str_mv	AT caterinagalandra impairedlearningfromregretanddisappointmentinalcoholusedisorder AT chiaracrespi impairedlearningfromregretanddisappointmentinalcoholusedisorder AT gianpaolobasso impairedlearningfromregretanddisappointmentinalcoholusedisorder AT nicolacanessa impairedlearningfromregretanddisappointmentinalcoholusedisorder
_version_	1718384030698700800

Impaired learning from regret and disappointment in alcohol use disorder

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