Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality

The detailed mechanisms of action of bactericidal antibiotics remain unclear. Here, Wong et al. show that these antibiotics induce cytoplasmic condensation through membrane damage and outflow of cytoplasmic contents, as well as accumulation of reactive metabolic by-products and lipid peroxidation, a...

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Autores principales:	Felix Wong, Jonathan M. Stokes, Bernardo Cervantes, Sider Penkov, Jens Friedrichs, Lars D. Renner, James J. Collins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb73ca87648a4649b92455775179f751
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spelling	oai:doaj.org-article:fb73ca87648a4649b92455775179f7512021-12-02T17:33:33ZCytoplasmic condensation induced by membrane damage is associated with antibiotic lethality10.1038/s41467-021-22485-62041-1723https://doaj.org/article/fb73ca87648a4649b92455775179f7512021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22485-6https://doaj.org/toc/2041-1723The detailed mechanisms of action of bactericidal antibiotics remain unclear. Here, Wong et al. show that these antibiotics induce cytoplasmic condensation through membrane damage and outflow of cytoplasmic contents, as well as accumulation of reactive metabolic by-products and lipid peroxidation, as part of their lethality.Felix WongJonathan M. StokesBernardo CervantesSider PenkovJens FriedrichsLars D. RennerJames J. CollinsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Felix Wong Jonathan M. Stokes Bernardo Cervantes Sider Penkov Jens Friedrichs Lars D. Renner James J. Collins Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
description	The detailed mechanisms of action of bactericidal antibiotics remain unclear. Here, Wong et al. show that these antibiotics induce cytoplasmic condensation through membrane damage and outflow of cytoplasmic contents, as well as accumulation of reactive metabolic by-products and lipid peroxidation, as part of their lethality.
format	article
author	Felix Wong Jonathan M. Stokes Bernardo Cervantes Sider Penkov Jens Friedrichs Lars D. Renner James J. Collins
author_facet	Felix Wong Jonathan M. Stokes Bernardo Cervantes Sider Penkov Jens Friedrichs Lars D. Renner James J. Collins
author_sort	Felix Wong
title	Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
title_short	Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
title_full	Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
title_fullStr	Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
title_full_unstemmed	Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
title_sort	cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb73ca87648a4649b92455775179f751
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Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality

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