The SAM domain of mouse SAMHD1 is critical for its activation and regulation

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

The sterile alpha-motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a dNTP phosphohydrolase that blocks HIV-1 infection by depleting cellular dNTPs. Here the authors present the structures of full-length mouse SAMHD1 in different nucleotide bound states and give insights into SAM...

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Autores principales: Olga Buzovetsky, Chenxiang Tang, Kirsten M. Knecht, Jenna M. Antonucci, Li Wu, Xiaoyun Ji, Yong Xiong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/fb7429a18680464e8fc8925c49c45e68
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spelling oai:doaj.org-article:fb7429a18680464e8fc8925c49c45e682021-12-02T14:39:06ZThe SAM domain of mouse SAMHD1 is critical for its activation and regulation10.1038/s41467-017-02783-82041-1723https://doaj.org/article/fb7429a18680464e8fc8925c49c45e682018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02783-8https://doaj.org/toc/2041-1723The sterile alpha-motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a dNTP phosphohydrolase that blocks HIV-1 infection by depleting cellular dNTPs. Here the authors present the structures of full-length mouse SAMHD1 in different nucleotide bound states and give insights into SAMHD1 activity regulation.Olga BuzovetskyChenxiang TangKirsten M. KnechtJenna M. AntonucciLi WuXiaoyun JiYong XiongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Olga Buzovetsky
Chenxiang Tang
Kirsten M. Knecht
Jenna M. Antonucci
Li Wu
Xiaoyun Ji
Yong Xiong
The SAM domain of mouse SAMHD1 is critical for its activation and regulation
description The sterile alpha-motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a dNTP phosphohydrolase that blocks HIV-1 infection by depleting cellular dNTPs. Here the authors present the structures of full-length mouse SAMHD1 in different nucleotide bound states and give insights into SAMHD1 activity regulation.
format article
author Olga Buzovetsky
Chenxiang Tang
Kirsten M. Knecht
Jenna M. Antonucci
Li Wu
Xiaoyun Ji
Yong Xiong
author_facet Olga Buzovetsky
Chenxiang Tang
Kirsten M. Knecht
Jenna M. Antonucci
Li Wu
Xiaoyun Ji
Yong Xiong
author_sort Olga Buzovetsky
title The SAM domain of mouse SAMHD1 is critical for its activation and regulation
title_short The SAM domain of mouse SAMHD1 is critical for its activation and regulation
title_full The SAM domain of mouse SAMHD1 is critical for its activation and regulation
title_fullStr The SAM domain of mouse SAMHD1 is critical for its activation and regulation
title_full_unstemmed The SAM domain of mouse SAMHD1 is critical for its activation and regulation
title_sort sam domain of mouse samhd1 is critical for its activation and regulation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/fb7429a18680464e8fc8925c49c45e68
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