The SAM domain of mouse SAMHD1 is critical for its activation and regulation

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

The sterile alpha-motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a dNTP phosphohydrolase that blocks HIV-1 infection by depleting cellular dNTPs. Here the authors present the structures of full-length mouse SAMHD1 in different nucleotide bound states and give insights into SAM...

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Autores principales: Olga Buzovetsky, Chenxiang Tang, Kirsten M. Knecht, Jenna M. Antonucci, Li Wu, Xiaoyun Ji, Yong Xiong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/fb7429a18680464e8fc8925c49c45e68
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