Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease
Beta asarone which is the major component of Acorus tatarinowii Schott, can pass through the blood-brain-barrier and affect the central nervous system. In the present study, effect of beta asarone on TNF-α level was investigated in β-amyloid-induced alzheimeric male rats. The adult male rats were ra...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | FA |
| Publicado: |
Islamic Azad University, Tabriz Branch
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/fb7667990971462f984c622cfbdb6f3c |
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| Sumario: | Beta asarone which is the major component of Acorus tatarinowii Schott, can pass through the blood-brain-barrier and affect the central nervous system. In the present study, effect of beta asarone on TNF-α level was investigated in β-amyloid-induced alzheimeric male rats. The adult male rats were randomly divided into 9 groups of 6: normal control, sham-operated control, β-asarone (12.5, 25 and 50 mg/kg PO, daily for 50 days), alzheimeric control (bilateral intrahippocampal injection of 4 µl of β-amyloid 1-42) and alzheimeric β-asarone receiving (12.5, 25 and 50 mg/kg PO β-asarone daily for 30 days following β-amyloid injection and subsequent doses of beta asarone for 3 weeks). The rats were sacrificed at the end of the experiment and the TNF-α level was measured in brain homogenate. Our results showed that administration of β-asarone (25 and 50 mg/kg) significantly decreased the TNF-α level (p<0.001) in alzheimeric rats. Thus, these results indicate that β-asarone is effective in providing protection against inflammation induced by β-amyloid. |
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