Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease
Beta asarone which is the major component of Acorus tatarinowii Schott, can pass through the blood-brain-barrier and affect the central nervous system. In the present study, effect of beta asarone on TNF-α level was investigated in β-amyloid-induced alzheimeric male rats. The adult male rats were ra...
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Islamic Azad University, Tabriz Branch
2021
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oai:doaj.org-article:fb7667990971462f984c622cfbdb6f3c2021-11-09T05:50:10ZEffect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease2322-47462476-698410.30495/jvcp.2020.670353https://doaj.org/article/fb7667990971462f984c622cfbdb6f3c2021-04-01T00:00:00Zhttp://jvcp.iaut.ac.ir/article_670353_eecad1eb082480a56e2ea18005442e5e.pdfhttps://doaj.org/toc/2322-4746https://doaj.org/toc/2476-6984Beta asarone which is the major component of Acorus tatarinowii Schott, can pass through the blood-brain-barrier and affect the central nervous system. In the present study, effect of beta asarone on TNF-α level was investigated in β-amyloid-induced alzheimeric male rats. The adult male rats were randomly divided into 9 groups of 6: normal control, sham-operated control, β-asarone (12.5, 25 and 50 mg/kg PO, daily for 50 days), alzheimeric control (bilateral intrahippocampal injection of 4 µl of β-amyloid 1-42) and alzheimeric β-asarone receiving (12.5, 25 and 50 mg/kg PO β-asarone daily for 30 days following β-amyloid injection and subsequent doses of beta asarone for 3 weeks). The rats were sacrificed at the end of the experiment and the TNF-α level was measured in brain homogenate. Our results showed that administration of β-asarone (25 and 50 mg/kg) significantly decreased the TNF-α level (p<0.001) in alzheimeric rats. Thus, these results indicate that β-asarone is effective in providing protection against inflammation induced by β-amyloid.Golshid SakiAkram EidiPejman MortazaviAkbar VahdatiNegar PanahiIslamic Azad University, Tabriz Brancharticlealzheimerβ-amyloidβ-asaronerattumor necrosis factor-alphaVeterinary medicineSF600-1100FAĀsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, Vol 15, Iss 1 (57) بهار, Pp 1-12 (2021) |
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alzheimer β-amyloid β-asarone rat tumor necrosis factor-alpha Veterinary medicine SF600-1100 |
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alzheimer β-amyloid β-asarone rat tumor necrosis factor-alpha Veterinary medicine SF600-1100 Golshid Saki Akram Eidi Pejman Mortazavi Akbar Vahdati Negar Panahi Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease |
| description |
Beta asarone which is the major component of Acorus tatarinowii Schott, can pass through the blood-brain-barrier and affect the central nervous system. In the present study, effect of beta asarone on TNF-α level was investigated in β-amyloid-induced alzheimeric male rats. The adult male rats were randomly divided into 9 groups of 6: normal control, sham-operated control, β-asarone (12.5, 25 and 50 mg/kg PO, daily for 50 days), alzheimeric control (bilateral intrahippocampal injection of 4 µl of β-amyloid 1-42) and alzheimeric β-asarone receiving (12.5, 25 and 50 mg/kg PO β-asarone daily for 30 days following β-amyloid injection and subsequent doses of beta asarone for 3 weeks). The rats were sacrificed at the end of the experiment and the TNF-α level was measured in brain homogenate. Our results showed that administration of β-asarone (25 and 50 mg/kg) significantly decreased the TNF-α level (p<0.001) in alzheimeric rats. Thus, these results indicate that β-asarone is effective in providing protection against inflammation induced by β-amyloid. |
| format |
article |
| author |
Golshid Saki Akram Eidi Pejman Mortazavi Akbar Vahdati Negar Panahi |
| author_facet |
Golshid Saki Akram Eidi Pejman Mortazavi Akbar Vahdati Negar Panahi |
| author_sort |
Golshid Saki |
| title |
Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease |
| title_short |
Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease |
| title_full |
Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease |
| title_fullStr |
Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease |
| title_full_unstemmed |
Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease |
| title_sort |
effect of beta asarone on concentration of tnf-α in a rat model of alzheimer’s disease |
| publisher |
Islamic Azad University, Tabriz Branch |
| publishDate |
2021 |
| url |
https://doaj.org/article/fb7667990971462f984c622cfbdb6f3c |
| work_keys_str_mv |
AT golshidsaki effectofbetaasaroneonconcentrationoftnfainaratmodelofalzheimersdisease AT akrameidi effectofbetaasaroneonconcentrationoftnfainaratmodelofalzheimersdisease AT pejmanmortazavi effectofbetaasaroneonconcentrationoftnfainaratmodelofalzheimersdisease AT akbarvahdati effectofbetaasaroneonconcentrationoftnfainaratmodelofalzheimersdisease AT negarpanahi effectofbetaasaroneonconcentrationoftnfainaratmodelofalzheimersdisease |
| _version_ |
1718441352208842753 |