Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts

There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantati...

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Autores principales:	Kentaro Kitano, Dana M. Schwartz, Haiyang Zhou, Sarah E. Gilpin, Gregory R. Wojtkiewicz, Xi Ren, Cesar A. Sommer, Amalia V. Capilla, Douglas J. Mathisen, Allan M. Goldstein, Gustavo Mostoslavsky, Harald C. Ott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb79aeb73b8e4a1bbacef326e30bded0
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spelling	oai:doaj.org-article:fb79aeb73b8e4a1bbacef326e30bded02021-12-02T17:01:22ZBioengineering of functional human induced pluripotent stem cell-derived intestinal grafts10.1038/s41467-017-00779-y2041-1723https://doaj.org/article/fb79aeb73b8e4a1bbacef326e30bded02017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00779-yhttps://doaj.org/toc/2041-1723There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantation in rats.Kentaro KitanoDana M. SchwartzHaiyang ZhouSarah E. GilpinGregory R. WojtkiewiczXi RenCesar A. SommerAmalia V. CapillaDouglas J. MathisenAllan M. GoldsteinGustavo MostoslavskyHarald C. OttNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kentaro Kitano Dana M. Schwartz Haiyang Zhou Sarah E. Gilpin Gregory R. Wojtkiewicz Xi Ren Cesar A. Sommer Amalia V. Capilla Douglas J. Mathisen Allan M. Goldstein Gustavo Mostoslavsky Harald C. Ott Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
description	There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantation in rats.
format	article
author	Kentaro Kitano Dana M. Schwartz Haiyang Zhou Sarah E. Gilpin Gregory R. Wojtkiewicz Xi Ren Cesar A. Sommer Amalia V. Capilla Douglas J. Mathisen Allan M. Goldstein Gustavo Mostoslavsky Harald C. Ott
author_facet	Kentaro Kitano Dana M. Schwartz Haiyang Zhou Sarah E. Gilpin Gregory R. Wojtkiewicz Xi Ren Cesar A. Sommer Amalia V. Capilla Douglas J. Mathisen Allan M. Goldstein Gustavo Mostoslavsky Harald C. Ott
author_sort	Kentaro Kitano
title	Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
title_short	Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
title_full	Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
title_fullStr	Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
title_full_unstemmed	Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
title_sort	bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fb79aeb73b8e4a1bbacef326e30bded0
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Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts

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