Optogenetic manipulation of calcium signals in single T cells in vivo

The ability to manipulate and monitor calcium signaling in cells in vivo would provide insights into signaling in an endogenous context. Here the authors develop a two-photon-responsive calcium actuator and reporter combination to monitor the effect of calcium actuation on T cell migration, adhesion...

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Autores principales:	Armelle Bohineust, Zacarias Garcia, Béatrice Corre, Fabrice Lemaître, Philippe Bousso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb7b30514bec4ff1a467119ddb06597e
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spelling	oai:doaj.org-article:fb7b30514bec4ff1a467119ddb06597e2021-12-02T15:39:20ZOptogenetic manipulation of calcium signals in single T cells in vivo10.1038/s41467-020-14810-22041-1723https://doaj.org/article/fb7b30514bec4ff1a467119ddb06597e2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14810-2https://doaj.org/toc/2041-1723The ability to manipulate and monitor calcium signaling in cells in vivo would provide insights into signaling in an endogenous context. Here the authors develop a two-photon-responsive calcium actuator and reporter combination to monitor the effect of calcium actuation on T cell migration, adhesion and chemokine release in vivo.Armelle BohineustZacarias GarciaBéatrice CorreFabrice LemaîtrePhilippe BoussoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Armelle Bohineust Zacarias Garcia Béatrice Corre Fabrice Lemaître Philippe Bousso Optogenetic manipulation of calcium signals in single T cells in vivo
description	The ability to manipulate and monitor calcium signaling in cells in vivo would provide insights into signaling in an endogenous context. Here the authors develop a two-photon-responsive calcium actuator and reporter combination to monitor the effect of calcium actuation on T cell migration, adhesion and chemokine release in vivo.
format	article
author	Armelle Bohineust Zacarias Garcia Béatrice Corre Fabrice Lemaître Philippe Bousso
author_facet	Armelle Bohineust Zacarias Garcia Béatrice Corre Fabrice Lemaître Philippe Bousso
author_sort	Armelle Bohineust
title	Optogenetic manipulation of calcium signals in single T cells in vivo
title_short	Optogenetic manipulation of calcium signals in single T cells in vivo
title_full	Optogenetic manipulation of calcium signals in single T cells in vivo
title_fullStr	Optogenetic manipulation of calcium signals in single T cells in vivo
title_full_unstemmed	Optogenetic manipulation of calcium signals in single T cells in vivo
title_sort	optogenetic manipulation of calcium signals in single t cells in vivo
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fb7b30514bec4ff1a467119ddb06597e
work_keys_str_mv	AT armellebohineust optogeneticmanipulationofcalciumsignalsinsingletcellsinvivo AT zacariasgarcia optogeneticmanipulationofcalciumsignalsinsingletcellsinvivo AT beatricecorre optogeneticmanipulationofcalciumsignalsinsingletcellsinvivo AT fabricelemaitre optogeneticmanipulationofcalciumsignalsinsingletcellsinvivo AT philippebousso optogeneticmanipulationofcalciumsignalsinsingletcellsinvivo
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Optogenetic manipulation of calcium signals in single T cells in vivo

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