Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties

Abstract Despite the prevalence of large (>5 cm2) articular cartilage defects involving underlying bone, current tissue-engineered therapies only address small defects. Tissue-engineered, anatomically shaped, native-like implants may address the need for off-the-shelf, tissue-repairing therapies...

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Autores principales:	Wendy E. Brown, Brian J. Huang, Jerry C. Hu, Kyriacos A. Athanasiou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/fb7c314ba07140b5a5ddd40d4b4fdf5a
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spelling	oai:doaj.org-article:fb7c314ba07140b5a5ddd40d4b4fdf5a2021-12-02T17:06:13ZEngineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties10.1038/s41536-021-00152-02057-3995https://doaj.org/article/fb7c314ba07140b5a5ddd40d4b4fdf5a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00152-0https://doaj.org/toc/2057-3995Abstract Despite the prevalence of large (>5 cm2) articular cartilage defects involving underlying bone, current tissue-engineered therapies only address small defects. Tissue-engineered, anatomically shaped, native-like implants may address the need for off-the-shelf, tissue-repairing therapies for large cartilage lesions. This study fabricated an osteochondral construct of translationally relevant geometry with robust functional properties. Scaffold-free, self-assembled neocartilage served as the chondral phase, and porous hydroxyapatite served as the osseous phase of the osteochondral constructs. Constructs in the shape and size of an ovine femoral condyle (31 × 14 mm) were assembled at day 4 (early) or day 10 (late) of neocartilage maturation. Early osteochondral assembly increased the interfacial interdigitation depth by 244%, interdigitation frequency by 438%, interfacial shear modulus by 243-fold, and ultimate interfacial shear strength by 4.9-fold, compared to late assembly. Toward the development of a bioprosthesis for the repair of cartilage lesions encompassing up to an entire condylar surface, this study generated a large, anatomically shaped osteochondral construct with robust interfacial mechanical properties and native-like neocartilage interdigitation.Wendy E. BrownBrian J. HuangJerry C. HuKyriacos A. AthanasiouNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Wendy E. Brown Brian J. Huang Jerry C. Hu Kyriacos A. Athanasiou Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
description	Abstract Despite the prevalence of large (>5 cm2) articular cartilage defects involving underlying bone, current tissue-engineered therapies only address small defects. Tissue-engineered, anatomically shaped, native-like implants may address the need for off-the-shelf, tissue-repairing therapies for large cartilage lesions. This study fabricated an osteochondral construct of translationally relevant geometry with robust functional properties. Scaffold-free, self-assembled neocartilage served as the chondral phase, and porous hydroxyapatite served as the osseous phase of the osteochondral constructs. Constructs in the shape and size of an ovine femoral condyle (31 × 14 mm) were assembled at day 4 (early) or day 10 (late) of neocartilage maturation. Early osteochondral assembly increased the interfacial interdigitation depth by 244%, interdigitation frequency by 438%, interfacial shear modulus by 243-fold, and ultimate interfacial shear strength by 4.9-fold, compared to late assembly. Toward the development of a bioprosthesis for the repair of cartilage lesions encompassing up to an entire condylar surface, this study generated a large, anatomically shaped osteochondral construct with robust interfacial mechanical properties and native-like neocartilage interdigitation.
format	article
author	Wendy E. Brown Brian J. Huang Jerry C. Hu Kyriacos A. Athanasiou
author_facet	Wendy E. Brown Brian J. Huang Jerry C. Hu Kyriacos A. Athanasiou
author_sort	Wendy E. Brown
title	Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
title_short	Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
title_full	Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
title_fullStr	Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
title_full_unstemmed	Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
title_sort	engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb7c314ba07140b5a5ddd40d4b4fdf5a
work_keys_str_mv	AT wendyebrown engineeringlargeanatomicallyshapedosteochondralconstructswithrobustinterfacialshearproperties AT brianjhuang engineeringlargeanatomicallyshapedosteochondralconstructswithrobustinterfacialshearproperties AT jerrychu engineeringlargeanatomicallyshapedosteochondralconstructswithrobustinterfacialshearproperties AT kyriacosaathanasiou engineeringlargeanatomicallyshapedosteochondralconstructswithrobustinterfacialshearproperties
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Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties

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