Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay

Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay

MiRNAs are known regulators of gene expression. Here the authors perform a large-scale massively parallel reporter assay to investigate the effect of a large number of designed 3′ UTR sequences on reporter expression and asses how miRNA regulatory elements features affect miRNA mediated repression....

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Autores principales: Ilya Vainberg Slutskin, Shira Weingarten-Gabbay, Ronit Nir, Adina Weinberger, Eran Segal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/fb7c84a2a18049cab8a44b70a61543f4
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spelling oai:doaj.org-article:fb7c84a2a18049cab8a44b70a61543f42021-12-02T15:33:47ZUnraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay10.1038/s41467-018-02980-z2041-1723https://doaj.org/article/fb7c84a2a18049cab8a44b70a61543f42018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02980-zhttps://doaj.org/toc/2041-1723MiRNAs are known regulators of gene expression. Here the authors perform a large-scale massively parallel reporter assay to investigate the effect of a large number of designed 3′ UTR sequences on reporter expression and asses how miRNA regulatory elements features affect miRNA mediated repression.Ilya Vainberg SlutskinShira Weingarten-GabbayRonit NirAdina WeinbergerEran SegalNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ilya Vainberg Slutskin
Shira Weingarten-Gabbay
Ronit Nir
Adina Weinberger
Eran Segal
Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
description MiRNAs are known regulators of gene expression. Here the authors perform a large-scale massively parallel reporter assay to investigate the effect of a large number of designed 3′ UTR sequences on reporter expression and asses how miRNA regulatory elements features affect miRNA mediated repression.
format article
author Ilya Vainberg Slutskin
Shira Weingarten-Gabbay
Ronit Nir
Adina Weinberger
Eran Segal
author_facet Ilya Vainberg Slutskin
Shira Weingarten-Gabbay
Ronit Nir
Adina Weinberger
Eran Segal
author_sort Ilya Vainberg Slutskin
title Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
title_short Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
title_full Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
title_fullStr Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
title_full_unstemmed Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
title_sort unraveling the determinants of microrna mediated regulation using a massively parallel reporter assay
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/fb7c84a2a18049cab8a44b70a61543f4
work_keys_str_mv AT ilyavainbergslutskin unravelingthedeterminantsofmicrornamediatedregulationusingamassivelyparallelreporterassay
AT shiraweingartengabbay unravelingthedeterminantsofmicrornamediatedregulationusingamassivelyparallelreporterassay
AT ronitnir unravelingthedeterminantsofmicrornamediatedregulationusingamassivelyparallelreporterassay
AT adinaweinberger unravelingthedeterminantsofmicrornamediatedregulationusingamassivelyparallelreporterassay
AT eransegal unravelingthedeterminantsofmicrornamediatedregulationusingamassivelyparallelreporterassay
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