Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension

Sophia K Mirza, Sandra M JohnsonDepartment of Ophthalmology, University of Virginia, Charlottesville, Virginia, USAAbstract: The medical treatment of glaucoma has evolved significantly over the past several decades. The main driving forces behind this evolution are the safety profiles and efficacy o...

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Autores principales:	Sophia K Mirza, Sandra M Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fb7deb8f77eb432482a25561a79211c7
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spelling	oai:doaj.org-article:fb7deb8f77eb432482a25561a79211c72021-12-02T05:30:26ZEfficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension1177-54671177-5483https://doaj.org/article/fb7deb8f77eb432482a25561a79211c72010-07-01T00:00:00Zhttp://www.dovepress.com/efficacy-and-patient-tolerability-of-travoprost-bak-free-solution-in-p-a4932https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Sophia K Mirza, Sandra M JohnsonDepartment of Ophthalmology, University of Virginia, Charlottesville, Virginia, USAAbstract: The medical treatment of glaucoma has evolved significantly over the past several decades. The main driving forces behind this evolution are the safety profiles and efficacy of these medications. Prostaglandin (PG) analogs are shown to be superior to older drugs in both efficacy and tolerability. Though there are much fewer side effects that manifest after using PG analogs, the adherence and compliance to medication regimens are surprisingly lower than expected. A commonly sited reason is the ocular irritation and inflammation with these medications. Much of this inflammation can be attributed to the preservative, benzalkonium chloride (BAK). The chronic clinical and subclinical inflammation becomes increasingly detrimental when filtration surgery fails from bleb fibrosis secondary to this hypercellularity. A BAK-free formulation of a PG analog recently became available. BAK-free travoprost is reviewed here. It has demonstrated equal efficacy and less ocular surface toxicity than its preserved counterparts. It is expected to serve as an instrumental resource in managing ocular hypertension and glaucoma in patients who demonstrate significant sensitivity to BAK. More randomized, controlled, double-blind studies are encouraged to evaluate its improved safety and tolerability.Keywords: glaucoma, benzalkonium chloride, Travatan Z, sofZia Sophia K MirzaSandra M JohnsonDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 877-888 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Sophia K Mirza Sandra M Johnson Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
description	Sophia K Mirza, Sandra M JohnsonDepartment of Ophthalmology, University of Virginia, Charlottesville, Virginia, USAAbstract: The medical treatment of glaucoma has evolved significantly over the past several decades. The main driving forces behind this evolution are the safety profiles and efficacy of these medications. Prostaglandin (PG) analogs are shown to be superior to older drugs in both efficacy and tolerability. Though there are much fewer side effects that manifest after using PG analogs, the adherence and compliance to medication regimens are surprisingly lower than expected. A commonly sited reason is the ocular irritation and inflammation with these medications. Much of this inflammation can be attributed to the preservative, benzalkonium chloride (BAK). The chronic clinical and subclinical inflammation becomes increasingly detrimental when filtration surgery fails from bleb fibrosis secondary to this hypercellularity. A BAK-free formulation of a PG analog recently became available. BAK-free travoprost is reviewed here. It has demonstrated equal efficacy and less ocular surface toxicity than its preserved counterparts. It is expected to serve as an instrumental resource in managing ocular hypertension and glaucoma in patients who demonstrate significant sensitivity to BAK. More randomized, controlled, double-blind studies are encouraged to evaluate its improved safety and tolerability.Keywords: glaucoma, benzalkonium chloride, Travatan Z, sofZia
format	article
author	Sophia K Mirza Sandra M Johnson
author_facet	Sophia K Mirza Sandra M Johnson
author_sort	Sophia K Mirza
title	Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
title_short	Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
title_full	Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
title_fullStr	Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
title_full_unstemmed	Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
title_sort	efficacy and patient tolerability of travoprost bak-free solution in patients with open-angle glaucoma and ocular hypertension
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/fb7deb8f77eb432482a25561a79211c7
work_keys_str_mv	AT sophiakmirza efficacyandpatienttolerabilityoftravoprostbakfreesolutioninpatientswithopenangleglaucomaandocularhypertension AT sandramjohnson efficacyandpatienttolerabilityoftravoprostbakfreesolutioninpatientswithopenangleglaucomaandocularhypertension
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Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension

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