A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

Many genetic loci have been linked to obesity, but knowledge of their functional mechanisms is limited. Here, the authors perform reporter assays and temporal functional genomics data generation to characterize obesity genetic loci and find that loci often harbor multiple functional variants.

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Autores principales:	Amelia C. Joslin, Débora R. Sobreira, Grace T. Hansen, Noboru J. Sakabe, Ivy Aneas, Lindsey E. Montefiori, Kathryn M. Farris, Jing Gu, Donna M. Lehman, Carole Ober, Xin He, Marcelo A. Nóbrega
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb7e892c9745454a8d337ec16d1a90bb
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spelling	oai:doaj.org-article:fb7e892c9745454a8d337ec16d1a90bb2021-12-02T17:41:19ZA functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci10.1038/s41467-021-25614-32041-1723https://doaj.org/article/fb7e892c9745454a8d337ec16d1a90bb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25614-3https://doaj.org/toc/2041-1723Many genetic loci have been linked to obesity, but knowledge of their functional mechanisms is limited. Here, the authors perform reporter assays and temporal functional genomics data generation to characterize obesity genetic loci and find that loci often harbor multiple functional variants.Amelia C. JoslinDébora R. SobreiraGrace T. HansenNoboru J. SakabeIvy AneasLindsey E. MontefioriKathryn M. FarrisJing GuDonna M. LehmanCarole OberXin HeMarcelo A. NóbregaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amelia C. Joslin Débora R. Sobreira Grace T. Hansen Noboru J. Sakabe Ivy Aneas Lindsey E. Montefiori Kathryn M. Farris Jing Gu Donna M. Lehman Carole Ober Xin He Marcelo A. Nóbrega A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci
description	Many genetic loci have been linked to obesity, but knowledge of their functional mechanisms is limited. Here, the authors perform reporter assays and temporal functional genomics data generation to characterize obesity genetic loci and find that loci often harbor multiple functional variants.
format	article
author	Amelia C. Joslin Débora R. Sobreira Grace T. Hansen Noboru J. Sakabe Ivy Aneas Lindsey E. Montefiori Kathryn M. Farris Jing Gu Donna M. Lehman Carole Ober Xin He Marcelo A. Nóbrega
author_facet	Amelia C. Joslin Débora R. Sobreira Grace T. Hansen Noboru J. Sakabe Ivy Aneas Lindsey E. Montefiori Kathryn M. Farris Jing Gu Donna M. Lehman Carole Ober Xin He Marcelo A. Nóbrega
author_sort	Amelia C. Joslin
title	A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci
title_short	A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci
title_full	A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci
title_fullStr	A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci
title_full_unstemmed	A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci
title_sort	functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated gwas loci
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb7e892c9745454a8d337ec16d1a90bb
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A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

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