Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Abstract Photon-counting detector computed tomography (PCD-CT) is a modern spectral imaging technique utilizing photon-counting detectors (PCDs). PCDs detect individual photons and classify them into fixed energy bins, thus enabling energy selective imaging, contrary to energy integrating detectors...

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Autores principales:	Petri Paakkari, Satu I. Inkinen, Miitu K. M. Honkanen, Mithilesh Prakash, Rubina Shaikh, Miika T. Nieminen, Mark W. Grinstaff, Janne T. A. Mäkelä, Juha Töyräs, Juuso T. J. Honkanen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb8607f2e5554412a3d588c24db14174
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spelling	oai:doaj.org-article:fb8607f2e5554412a3d588c24db141742021-12-02T13:20:11ZQuantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health10.1038/s41598-021-84800-x2045-2322https://doaj.org/article/fb8607f2e5554412a3d588c24db141742021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84800-xhttps://doaj.org/toc/2045-2322Abstract Photon-counting detector computed tomography (PCD-CT) is a modern spectral imaging technique utilizing photon-counting detectors (PCDs). PCDs detect individual photons and classify them into fixed energy bins, thus enabling energy selective imaging, contrary to energy integrating detectors that detects and sums the total energy from all photons during acquisition. The structure and composition of the articular cartilage cannot be detected with native CT imaging but can be assessed using contrast-enhancement. Spectral imaging allows simultaneous decomposition of multiple contrast agents, which can be used to target and highlight discrete cartilage properties. Here we report, for the first time, the use of PCD-CT to quantify a cationic iodinated CA4+ (targeting proteoglycans) and a non-ionic gadolinium-based gadoteridol (reflecting water content) contrast agents inside human osteochondral tissue (n = 53). We performed PCD-CT scanning at diffusion equilibrium and compared the results against reference data of biomechanical and optical density measurements, and Mankin scoring. PCD-CT enables simultaneous quantification of the two contrast agent concentrations inside cartilage and the results correlate with the structural and functional reference parameters. With improved soft tissue contrast and assessment of proteoglycan and water contents, PCD-CT with the dual contrast agent method is of potential use for the detection and monitoring of osteoarthritis.Petri PaakkariSatu I. InkinenMiitu K. M. HonkanenMithilesh PrakashRubina ShaikhMiika T. NieminenMark W. GrinstaffJanne T. A. MäkeläJuha TöyräsJuuso T. J. HonkanenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Petri Paakkari Satu I. Inkinen Miitu K. M. Honkanen Mithilesh Prakash Rubina Shaikh Miika T. Nieminen Mark W. Grinstaff Janne T. A. Mäkelä Juha Töyräs Juuso T. J. Honkanen Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health
description	Abstract Photon-counting detector computed tomography (PCD-CT) is a modern spectral imaging technique utilizing photon-counting detectors (PCDs). PCDs detect individual photons and classify them into fixed energy bins, thus enabling energy selective imaging, contrary to energy integrating detectors that detects and sums the total energy from all photons during acquisition. The structure and composition of the articular cartilage cannot be detected with native CT imaging but can be assessed using contrast-enhancement. Spectral imaging allows simultaneous decomposition of multiple contrast agents, which can be used to target and highlight discrete cartilage properties. Here we report, for the first time, the use of PCD-CT to quantify a cationic iodinated CA4+ (targeting proteoglycans) and a non-ionic gadolinium-based gadoteridol (reflecting water content) contrast agents inside human osteochondral tissue (n = 53). We performed PCD-CT scanning at diffusion equilibrium and compared the results against reference data of biomechanical and optical density measurements, and Mankin scoring. PCD-CT enables simultaneous quantification of the two contrast agent concentrations inside cartilage and the results correlate with the structural and functional reference parameters. With improved soft tissue contrast and assessment of proteoglycan and water contents, PCD-CT with the dual contrast agent method is of potential use for the detection and monitoring of osteoarthritis.
format	article
author	Petri Paakkari Satu I. Inkinen Miitu K. M. Honkanen Mithilesh Prakash Rubina Shaikh Miika T. Nieminen Mark W. Grinstaff Janne T. A. Mäkelä Juha Töyräs Juuso T. J. Honkanen
author_facet	Petri Paakkari Satu I. Inkinen Miitu K. M. Honkanen Mithilesh Prakash Rubina Shaikh Miika T. Nieminen Mark W. Grinstaff Janne T. A. Mäkelä Juha Töyräs Juuso T. J. Honkanen
author_sort	Petri Paakkari
title	Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health
title_short	Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health
title_full	Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health
title_fullStr	Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health
title_full_unstemmed	Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health
title_sort	quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb8607f2e5554412a3d588c24db14174
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Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

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