LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS

Abstract. The aim of present study was to investigate some indexes of immune deficiency, antimicrobial protective mechanisms, and lipid-releasing ability of leukocytes in patients with community-acquired pneumonia. The study groups involved fifty-two pneumonia patients and 26 healthy people. The pat...

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Autores principales:	V. Ju. Mishlanov, P. N. Barlamov, N. S. Morozova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	antimicrobial defense cytokines leukocytes pneumonia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/fb8a4250275e4ccba2b3e37797d960df
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spelling	oai:doaj.org-article:fb8a4250275e4ccba2b3e37797d960df2021-11-18T08:03:43ZLEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS1563-06252313-741X10.15789/1563-0625-2012-6-555-560https://doaj.org/article/fb8a4250275e4ccba2b3e37797d960df2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/639https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of present study was to investigate some indexes of immune deficiency, antimicrobial protective mechanisms, and lipid-releasing ability of leukocytes in patients with community-acquired pneumonia. The study groups involved fifty-two pneumonia patients and 26 healthy people. The patients were subdivided into two age groups, 20-40, and 41-60 years old. We classified the laboratory findings according to severity and clinical phase of the disease, and smoking status. Evaluation of immune deficiency included filling of special questionnaire, drawing of scores, and stratification into two groups, according to presence or absence of clinical immune deficiency. Serum concentrations of IL-6, IL-8, TNFαα and CRP, were detected by enzyme immune assay. An original technique was applied for detection of lipid-releasing ability of leukocytes. It was shown that 46 per cent of pneumonia patients showed clinical signs of immune insufficiency, being more common in cases of severe pneumonia, or extensive lung damage, according to radiological data. A relative quantitative deficiency of serum IL-8 and TNFαα was revealed in patients with severe pneumonia, accompanied by elevated serum IL-6. Lipid-releasing ability of leukocytes was significantly decreased among patients between 20 to 40 years old. This deficiency was more expressed in patients with severe pneumonia, and it returned to near- normal levels upon clinical resolution of the disease.V. Ju. MishlanovP. N. BarlamovN. S. MorozovaSPb RAACIarticleantimicrobial defensecytokinesleukocytespneumoniaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 555-560 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	antimicrobial defense cytokines leukocytes pneumonia Immunologic diseases. Allergy RC581-607
spellingShingle	antimicrobial defense cytokines leukocytes pneumonia Immunologic diseases. Allergy RC581-607 V. Ju. Mishlanov P. N. Barlamov N. S. Morozova LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS
description	Abstract. The aim of present study was to investigate some indexes of immune deficiency, antimicrobial protective mechanisms, and lipid-releasing ability of leukocytes in patients with community-acquired pneumonia. The study groups involved fifty-two pneumonia patients and 26 healthy people. The patients were subdivided into two age groups, 20-40, and 41-60 years old. We classified the laboratory findings according to severity and clinical phase of the disease, and smoking status. Evaluation of immune deficiency included filling of special questionnaire, drawing of scores, and stratification into two groups, according to presence or absence of clinical immune deficiency. Serum concentrations of IL-6, IL-8, TNFαα and CRP, were detected by enzyme immune assay. An original technique was applied for detection of lipid-releasing ability of leukocytes. It was shown that 46 per cent of pneumonia patients showed clinical signs of immune insufficiency, being more common in cases of severe pneumonia, or extensive lung damage, according to radiological data. A relative quantitative deficiency of serum IL-8 and TNFαα was revealed in patients with severe pneumonia, accompanied by elevated serum IL-6. Lipid-releasing ability of leukocytes was significantly decreased among patients between 20 to 40 years old. This deficiency was more expressed in patients with severe pneumonia, and it returned to near- normal levels upon clinical resolution of the disease.
format	article
author	V. Ju. Mishlanov P. N. Barlamov N. S. Morozova
author_facet	V. Ju. Mishlanov P. N. Barlamov N. S. Morozova
author_sort	V. Ju. Mishlanov
title	LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS
title_short	LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS
title_full	LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS
title_fullStr	LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS
title_full_unstemmed	LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS
title_sort	leukocytes lipid release ability and certain immune deficiency criteria in community acquired pneumoniae patients
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/fb8a4250275e4ccba2b3e37797d960df
work_keys_str_mv	AT vjumishlanov leukocyteslipidreleaseabilityandcertainimmunedeficiencycriteriaincommunityacquiredpneumoniaepatients AT pnbarlamov leukocyteslipidreleaseabilityandcertainimmunedeficiencycriteriaincommunityacquiredpneumoniaepatients AT nsmorozova leukocyteslipidreleaseabilityandcertainimmunedeficiencycriteriaincommunityacquiredpneumoniaepatients
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LEUKOCYTES LIPID RELEASE ABILITY AND CERTAIN IMMUNE DEFICIENCY CRITERIA IN COMMUNITY ACQUIRED PNEUMONIAE PATIENTS

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