PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.

PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.

Small RNAs--including piRNAs, miRNAs, and endogenous siRNAs--bind Argonaute proteins to form RNA silencing complexes that target coding genes, transposons, and aberrant RNAs. To assess the requirements for endogenous siRNA formation and activity in Caenorhabditis elegans, we developed a GFP-based se...

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Detalles Bibliográficos
Autores principales: Taiowa A Montgomery, Young-Soo Rim, Chi Zhang, Robert H Dowen, Carolyn M Phillips, Sylvia E J Fischer, Gary Ruvkun
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/fb8ab92b94564be8b53cf0be267f40b2
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