Landscape of allele-specific transcription factor binding in the human genome

Landscape of allele-specific transcription factor binding in the human genome

Single-nucleotide variants in enhancers or promoters may affect gene transcription by altering transcription factor binding sites. Here the authors present a meta-analysis empowered by a new statistical method covering thousands of ChIP-Seq experiments resulting in the identification of more than 50...

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Auteurs principaux: Sergey Abramov, Alexandr Boytsov, Daria Bykova, Dmitry D. Penzar, Ivan Yevshin, Semyon K. Kolmykov, Marina V. Fridman, Alexander V. Favorov, Ilya E. Vorontsov, Eugene Baulin, Fedor Kolpakov, Vsevolod J. Makeev, Ivan V. Kulakovskiy
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/fb8abbc7f0654d9bb7b8ee5f2d4d9a03
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Résumé:Single-nucleotide variants in enhancers or promoters may affect gene transcription by altering transcription factor binding sites. Here the authors present a meta-analysis empowered by a new statistical method covering thousands of ChIP-Seq experiments resulting in the identification of more than 500 thousand allele-specific binding (ASB) events in the human genome.

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