Landscape of allele-specific transcription factor binding in the human genome

Single-nucleotide variants in enhancers or promoters may affect gene transcription by altering transcription factor binding sites. Here the authors present a meta-analysis empowered by a new statistical method covering thousands of ChIP-Seq experiments resulting in the identification of more than 50...

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Autores principales:	Sergey Abramov, Alexandr Boytsov, Daria Bykova, Dmitry D. Penzar, Ivan Yevshin, Semyon K. Kolmykov, Marina V. Fridman, Alexander V. Favorov, Ilya E. Vorontsov, Eugene Baulin, Fedor Kolpakov, Vsevolod J. Makeev, Ivan V. Kulakovskiy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb8abbc7f0654d9bb7b8ee5f2d4d9a03
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spelling	oai:doaj.org-article:fb8abbc7f0654d9bb7b8ee5f2d4d9a032021-12-02T17:15:21ZLandscape of allele-specific transcription factor binding in the human genome10.1038/s41467-021-23007-02041-1723https://doaj.org/article/fb8abbc7f0654d9bb7b8ee5f2d4d9a032021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23007-0https://doaj.org/toc/2041-1723Single-nucleotide variants in enhancers or promoters may affect gene transcription by altering transcription factor binding sites. Here the authors present a meta-analysis empowered by a new statistical method covering thousands of ChIP-Seq experiments resulting in the identification of more than 500 thousand allele-specific binding (ASB) events in the human genome.Sergey AbramovAlexandr BoytsovDaria BykovaDmitry D. PenzarIvan YevshinSemyon K. KolmykovMarina V. FridmanAlexander V. FavorovIlya E. VorontsovEugene BaulinFedor KolpakovVsevolod J. MakeevIvan V. KulakovskiyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sergey Abramov Alexandr Boytsov Daria Bykova Dmitry D. Penzar Ivan Yevshin Semyon K. Kolmykov Marina V. Fridman Alexander V. Favorov Ilya E. Vorontsov Eugene Baulin Fedor Kolpakov Vsevolod J. Makeev Ivan V. Kulakovskiy Landscape of allele-specific transcription factor binding in the human genome
description	Single-nucleotide variants in enhancers or promoters may affect gene transcription by altering transcription factor binding sites. Here the authors present a meta-analysis empowered by a new statistical method covering thousands of ChIP-Seq experiments resulting in the identification of more than 500 thousand allele-specific binding (ASB) events in the human genome.
format	article
author	Sergey Abramov Alexandr Boytsov Daria Bykova Dmitry D. Penzar Ivan Yevshin Semyon K. Kolmykov Marina V. Fridman Alexander V. Favorov Ilya E. Vorontsov Eugene Baulin Fedor Kolpakov Vsevolod J. Makeev Ivan V. Kulakovskiy
author_facet	Sergey Abramov Alexandr Boytsov Daria Bykova Dmitry D. Penzar Ivan Yevshin Semyon K. Kolmykov Marina V. Fridman Alexander V. Favorov Ilya E. Vorontsov Eugene Baulin Fedor Kolpakov Vsevolod J. Makeev Ivan V. Kulakovskiy
author_sort	Sergey Abramov
title	Landscape of allele-specific transcription factor binding in the human genome
title_short	Landscape of allele-specific transcription factor binding in the human genome
title_full	Landscape of allele-specific transcription factor binding in the human genome
title_fullStr	Landscape of allele-specific transcription factor binding in the human genome
title_full_unstemmed	Landscape of allele-specific transcription factor binding in the human genome
title_sort	landscape of allele-specific transcription factor binding in the human genome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb8abbc7f0654d9bb7b8ee5f2d4d9a03
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Landscape of allele-specific transcription factor binding in the human genome

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