Evaluating the translational value of postmortem brain reperfusion technology

A novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and...

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Autor principal:	Nair-Collins Michael
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	brain ischemia brain death brain perfusion sus scrofa domesticus neuroresuscitation neurorehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/fb8c985a767f4bff9adddf58d3ade423
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spelling	oai:doaj.org-article:fb8c985a767f4bff9adddf58d3ade4232021-12-05T14:11:05ZEvaluating the translational value of postmortem brain reperfusion technology2081-693610.1515/tnsci-2020-0179https://doaj.org/article/fb8c985a767f4bff9adddf58d3ade4232021-07-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0179https://doaj.org/toc/2081-6936A novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and its methodology, providing several reasons for skepticism. This includes: all phenomena were observed at different degrees of hypothermia; the physiological and biochemical milieu of the experimental preparation is radically different than the clinical setting of hypoxic-ischemic brain injury; and the study is confounded by uncontrolled traumatic brain injury and lifelong stress in all the animals.Nair-Collins MichaelDe Gruyterarticlebrain ischemiabrain deathbrain perfusionsus scrofa domesticusneuroresuscitationneurorehabilitationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 297-300 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain ischemia brain death brain perfusion sus scrofa domesticus neuroresuscitation neurorehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	brain ischemia brain death brain perfusion sus scrofa domesticus neuroresuscitation neurorehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Nair-Collins Michael Evaluating the translational value of postmortem brain reperfusion technology
description	A novel pulsatile-perfusion technology, dubbed BrainEx, has been shown to restore microcirculation and cellular functions in the pig brain, 4 h postmortem. This technology has generated enthusiasm for its translational value for human neuroresuscitation. I offer a critical analysis of the study and its methodology, providing several reasons for skepticism. This includes: all phenomena were observed at different degrees of hypothermia; the physiological and biochemical milieu of the experimental preparation is radically different than the clinical setting of hypoxic-ischemic brain injury; and the study is confounded by uncontrolled traumatic brain injury and lifelong stress in all the animals.
format	article
author	Nair-Collins Michael
author_facet	Nair-Collins Michael
author_sort	Nair-Collins Michael
title	Evaluating the translational value of postmortem brain reperfusion technology
title_short	Evaluating the translational value of postmortem brain reperfusion technology
title_full	Evaluating the translational value of postmortem brain reperfusion technology
title_fullStr	Evaluating the translational value of postmortem brain reperfusion technology
title_full_unstemmed	Evaluating the translational value of postmortem brain reperfusion technology
title_sort	evaluating the translational value of postmortem brain reperfusion technology
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/fb8c985a767f4bff9adddf58d3ade423
work_keys_str_mv	AT naircollinsmichael evaluatingthetranslationalvalueofpostmortembrainreperfusiontechnology
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Evaluating the translational value of postmortem brain reperfusion technology

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