Conjunctival melanoma: a review of conceptual and treatment advances

Li-Anne Lim,1 Michele C Madigan,1,2 R Max Conway1 1Save Sight Institute, Clinical Ophthalmology, The University of Sydney, Sydney, New South Wales, Australia; 2School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia Abstract: The aim of this stud...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lim LA, Madigan MC, Conway RM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fb8d68fcf9004dce93dd4313d37dad80
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fb8d68fcf9004dce93dd4313d37dad80
record_format	dspace
spelling	oai:doaj.org-article:fb8d68fcf9004dce93dd4313d37dad802021-12-02T02:08:22ZConjunctival melanoma: a review of conceptual and treatment advances1177-54671177-5483https://doaj.org/article/fb8d68fcf9004dce93dd4313d37dad802013-03-01T00:00:00Zhttp://www.dovepress.com/conjunctival-melanoma-a-review-of-conceptual-and-treatment-advances-a12453https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Li-Anne Lim,1 Michele C Madigan,1,2 R Max Conway1 1Save Sight Institute, Clinical Ophthalmology, The University of Sydney, Sydney, New South Wales, Australia; 2School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia Abstract: The aim of this study was to review the available literature and identify recent advances in the classification and management of conjunctival melanoma (CM) for clinicians working in this field. English-based articles were identified using the MEDLINE&reg; database, and additional cited works not detected in the initial search were also obtained. Articles were assessed according to the Australian National Health and Medical Research Council levels of evidence criteria. Review of the literature indicated that the current classification and management of CM is predominantly based upon primarily nonrandomized, single-institution, retrospective case series. While these studies provide the basis for the recent seventh edition of the tumor node metastasis staging classification, this classification more accurately reflects the current knowledge of prognostic factors for CM. Application of this revised classification system together with prospective trials will provide the opportunity for future consistent and comparable data collection across centers, and it will improve the quality of evidence upon which current classification and management of CM is based. Furthermore, the high risk of local recurrence with current standard management suggests that adjuvant therapy, particularly mitomycin C and/or brachytherapy, may improve outcomes regardless of clinical staging. Finally, the use of sentinel lymph node biopsy may have significant benefit for a select group of CM patients.&nbsp; Keywords: adjuvant therapy, melanoma in situ, mitomycin C, metastasesLim LAMadigan MCConway RMDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 521-531 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Lim LA Madigan MC Conway RM Conjunctival melanoma: a review of conceptual and treatment advances
description	Li-Anne Lim,1 Michele C Madigan,1,2 R Max Conway1 1Save Sight Institute, Clinical Ophthalmology, The University of Sydney, Sydney, New South Wales, Australia; 2School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia Abstract: The aim of this study was to review the available literature and identify recent advances in the classification and management of conjunctival melanoma (CM) for clinicians working in this field. English-based articles were identified using the MEDLINE&reg; database, and additional cited works not detected in the initial search were also obtained. Articles were assessed according to the Australian National Health and Medical Research Council levels of evidence criteria. Review of the literature indicated that the current classification and management of CM is predominantly based upon primarily nonrandomized, single-institution, retrospective case series. While these studies provide the basis for the recent seventh edition of the tumor node metastasis staging classification, this classification more accurately reflects the current knowledge of prognostic factors for CM. Application of this revised classification system together with prospective trials will provide the opportunity for future consistent and comparable data collection across centers, and it will improve the quality of evidence upon which current classification and management of CM is based. Furthermore, the high risk of local recurrence with current standard management suggests that adjuvant therapy, particularly mitomycin C and/or brachytherapy, may improve outcomes regardless of clinical staging. Finally, the use of sentinel lymph node biopsy may have significant benefit for a select group of CM patients.&nbsp; Keywords: adjuvant therapy, melanoma in situ, mitomycin C, metastases
format	article
author	Lim LA Madigan MC Conway RM
author_facet	Lim LA Madigan MC Conway RM
author_sort	Lim LA
title	Conjunctival melanoma: a review of conceptual and treatment advances
title_short	Conjunctival melanoma: a review of conceptual and treatment advances
title_full	Conjunctival melanoma: a review of conceptual and treatment advances
title_fullStr	Conjunctival melanoma: a review of conceptual and treatment advances
title_full_unstemmed	Conjunctival melanoma: a review of conceptual and treatment advances
title_sort	conjunctival melanoma: a review of conceptual and treatment advances
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/fb8d68fcf9004dce93dd4313d37dad80
work_keys_str_mv	AT limla conjunctivalmelanomaareviewofconceptualandtreatmentadvances AT madiganmc conjunctivalmelanomaareviewofconceptualandtreatmentadvances AT conwayrm conjunctivalmelanomaareviewofconceptualandtreatmentadvances
_version_	1718402690108620800

Conjunctival melanoma: a review of conceptual and treatment advances

Ejemplares similares