Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells

One of the most severe mental disorder which leads to a disturbance in the percipience of reality is named schizophrenia. Schizophrenia is a combination of hallucinations, delusions, and mental disorders that the severity of them impairs healthy thinking and behavior, and in general, the inability t...

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Autor principal:	Nassim Rastgar
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Beheshti University of Medical Sciences 2020
Materias:	schizophrenia ips cells ipscs gaba da hypothesis Medicine R
Acceso en línea:	https://doaj.org/article/fb91f5241bd74a35a37b16af383b32fb
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spelling	oai:doaj.org-article:fb91f5241bd74a35a37b16af383b32fb2021-11-16T11:06:27ZSchizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells2383-18712383-209610.34172/icnj.2020.21https://doaj.org/article/fb91f5241bd74a35a37b16af383b32fb2020-10-01T00:00:00Zhttps://journals.sbmu.ac.ir/neuroscience/article/view/31154/25810https://doaj.org/toc/2383-1871https://doaj.org/toc/2383-2096One of the most severe mental disorder which leads to a disturbance in the percipience of reality is named schizophrenia. Schizophrenia is a combination of hallucinations, delusions, and mental disorders that the severity of them impairs healthy thinking and behavior, and in general, the inability to perform daily activities. Behavioral, intellectual, and emotional disorders indicate the widespread impact of schizophrenia on various aspects of mental health. Schizophrenia’s signs and symptoms of schizophrenia are varied, although delusions, hallucinations, or disorganized speech included in common symptoms. Dopamine has been the main subject of much research on schizophrenia for decades. Molecular neuroimaging studies to explore the dopamine system (DA system) in vivo have revealed that Schizophrenia is first associated with a defect in the striatum and then with a defect in extrastriatal regions with centralizing on cortex and midbrain. Also, the gamma-aminobutyric acid (GABA) mRNA dysregulation and neuroinflammatory mechanisms can be useful in schizophrenia. Various medications such as antipsychotic drugs used to the aim of treating this disease, but they can just decline or improve the positive symptoms. Modeling neurodevelopment and synaptic connection defects by induced human pluripotent stem cells have made appropriate circumstances to eliminate schizophrenia treatment barriers. With the development of cell therapies and induced pluripotent stem cells (iPSCs), there is a hope that the negative symptoms can be improved.Nassim RastgarShahid Beheshti University of Medical Sciencesarticleschizophreniaips cellsipscsgabada hypothesisMedicineRENInternational Clinical Neuroscience Journal, Vol 7, Iss 4, Pp 171-178 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia ips cells ipscs gaba da hypothesis Medicine R
spellingShingle	schizophrenia ips cells ipscs gaba da hypothesis Medicine R Nassim Rastgar Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells
description	One of the most severe mental disorder which leads to a disturbance in the percipience of reality is named schizophrenia. Schizophrenia is a combination of hallucinations, delusions, and mental disorders that the severity of them impairs healthy thinking and behavior, and in general, the inability to perform daily activities. Behavioral, intellectual, and emotional disorders indicate the widespread impact of schizophrenia on various aspects of mental health. Schizophrenia’s signs and symptoms of schizophrenia are varied, although delusions, hallucinations, or disorganized speech included in common symptoms. Dopamine has been the main subject of much research on schizophrenia for decades. Molecular neuroimaging studies to explore the dopamine system (DA system) in vivo have revealed that Schizophrenia is first associated with a defect in the striatum and then with a defect in extrastriatal regions with centralizing on cortex and midbrain. Also, the gamma-aminobutyric acid (GABA) mRNA dysregulation and neuroinflammatory mechanisms can be useful in schizophrenia. Various medications such as antipsychotic drugs used to the aim of treating this disease, but they can just decline or improve the positive symptoms. Modeling neurodevelopment and synaptic connection defects by induced human pluripotent stem cells have made appropriate circumstances to eliminate schizophrenia treatment barriers. With the development of cell therapies and induced pluripotent stem cells (iPSCs), there is a hope that the negative symptoms can be improved.
format	article
author	Nassim Rastgar
author_facet	Nassim Rastgar
author_sort	Nassim Rastgar
title	Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells
title_short	Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells
title_full	Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells
title_fullStr	Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells
title_full_unstemmed	Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells
title_sort	schizophrenia; recent cognitive and treatment approaches using induced pluripotent stem cells
publisher	Shahid Beheshti University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/fb91f5241bd74a35a37b16af383b32fb
work_keys_str_mv	AT nassimrastgar schizophreniarecentcognitiveandtreatmentapproachesusinginducedpluripotentstemcells
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Schizophrenia; Recent Cognitive and Treatment Approaches Using Induced Pluripotent Stem Cells

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