Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease

Abstract A link between sex hormones and B-cell activating factor (BAFF), a crucial immunoregulator of autoimmune thyroid disease (AITD), may exist. The study aimed to elucidate the role of estrogen (E2) in regulating BAFF in Graves' disease (GD). In clinical samples, serum BAFF levels were hig...

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Autores principales:	Chao-Wen Cheng, Wen-Fang Fang, Kam-Tsun Tang, Jiunn-Diann Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb9203b171414f159c482ee2b8acc310
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spelling	oai:doaj.org-article:fb9203b171414f159c482ee2b8acc3102021-11-08T10:46:28ZPossible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease10.1038/s41598-021-00903-52045-2322https://doaj.org/article/fb9203b171414f159c482ee2b8acc3102021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00903-5https://doaj.org/toc/2045-2322Abstract A link between sex hormones and B-cell activating factor (BAFF), a crucial immunoregulator of autoimmune thyroid disease (AITD), may exist. The study aimed to elucidate the role of estrogen (E2) in regulating BAFF in Graves' disease (GD). In clinical samples, serum BAFF levels were higher in women than in men in both the GD and control groups. serum BAFF levels were associated with thyroid-stimulating hormone receptor antibody levels and thyroid function only in women and not in men. BAFF transcripts in peripheral blood mononuclear cells were higher in women with GD than those in the control group. Among GD patients with the AA genotype of rs2893321, women had higher BAFF transcripts and protein levels than men. In the progression of a spontaneous autoimmune thyroiditis (SAT) murine model, NOD.H-2h4, serum free thyroxine and BAFF levels were higher in female than in male mice. Moreover, exogenous E2 treatment increased serum BAFF levels in male SAT mice. Meanwhile, female SAT mice exhibited higher thyroid BAFF transcripts levels than either the E2-treated or untreated male SAT mouse groups. Our results showed that E2 might be implicated in modulating BAFF expression, and support a possible mechanism for the higher incidence of AITD in women.Chao-Wen ChengWen-Fang FangKam-Tsun TangJiunn-Diann LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chao-Wen Cheng Wen-Fang Fang Kam-Tsun Tang Jiunn-Diann Lin Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease
description	Abstract A link between sex hormones and B-cell activating factor (BAFF), a crucial immunoregulator of autoimmune thyroid disease (AITD), may exist. The study aimed to elucidate the role of estrogen (E2) in regulating BAFF in Graves' disease (GD). In clinical samples, serum BAFF levels were higher in women than in men in both the GD and control groups. serum BAFF levels were associated with thyroid-stimulating hormone receptor antibody levels and thyroid function only in women and not in men. BAFF transcripts in peripheral blood mononuclear cells were higher in women with GD than those in the control group. Among GD patients with the AA genotype of rs2893321, women had higher BAFF transcripts and protein levels than men. In the progression of a spontaneous autoimmune thyroiditis (SAT) murine model, NOD.H-2h4, serum free thyroxine and BAFF levels were higher in female than in male mice. Moreover, exogenous E2 treatment increased serum BAFF levels in male SAT mice. Meanwhile, female SAT mice exhibited higher thyroid BAFF transcripts levels than either the E2-treated or untreated male SAT mouse groups. Our results showed that E2 might be implicated in modulating BAFF expression, and support a possible mechanism for the higher incidence of AITD in women.
format	article
author	Chao-Wen Cheng Wen-Fang Fang Kam-Tsun Tang Jiunn-Diann Lin
author_facet	Chao-Wen Cheng Wen-Fang Fang Kam-Tsun Tang Jiunn-Diann Lin
author_sort	Chao-Wen Cheng
title	Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease
title_short	Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease
title_full	Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease
title_fullStr	Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease
title_full_unstemmed	Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease
title_sort	possible interplay between estrogen and the baff may modify thyroid activity in graves’ disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb9203b171414f159c482ee2b8acc310
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Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves’ disease

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