Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.

<h4>Background</h4>Right ventricular (RV) pacing generates regional disparities in electrical activation and mechanical function (ventricular dyssynchrony). In contrast, left ventricular (LV) or biventricular (BIV) pacing can improve cardiac efficiency in the setting of ventricular dyssy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michal Mor, Wesam Mulla, Sigal Elyagon, Hovav Gabay, Shani Dror, Yoram Etzion, Noah Liel-Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb9205fa16a941e6853be97b1cfda2c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fb9205fa16a941e6853be97b1cfda2c8
record_format	dspace
spelling	oai:doaj.org-article:fb9205fa16a941e6853be97b1cfda2c82021-11-18T08:16:20ZSpeckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.1932-620310.1371/journal.pone.0099191https://doaj.org/article/fb9205fa16a941e6853be97b1cfda2c82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24915191/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Right ventricular (RV) pacing generates regional disparities in electrical activation and mechanical function (ventricular dyssynchrony). In contrast, left ventricular (LV) or biventricular (BIV) pacing can improve cardiac efficiency in the setting of ventricular dyssynchrony, constituting the rationale for cardiac resynchronization therapy (CRT). Animal models of ventricular dyssynchrony and CRT currently relay on large mammals which are expensive and not readily available to most researchers. We developed a methodology for double-site epicardial pacing in conscious rats. Here, following post-operative recovery, we compared the effects of various pacing modes on LV dyssynchrony in normal rats and in rats with ischemic cardiomyopathy.<h4>Methods</h4>Two bipolar electrodes were implanted in rats as follows: Group A (n = 6) right atrial (RA) and RV sites; Group B (n = 7) RV and LV sites; Group C (n = 8) as in group B in combination with left coronary artery ligation. Electrodes were exteriorized through the back. Following post-operative recovery, two-dimensional transthoracic echocardiography was performed during pacing through the different electrodes. Segmental systolic circumferential strain (Ecc) was used to evaluate LV dyssynchrony.<h4>Results</h4>In normal rats, RV pacing induced marked LV dyssynchrony compared to RA pacing or sinus rhythm, as measured by the standard deviation (SD) of segmental time to peak Ecc, SD of peak Ecc, and the average delay between opposing ventricular segments. LV pacing and, to a greater extend BIV pacing diminished the LV dyssynchrony compared to RV pacing. In rats with extensive MI, the effects of LV and BIV pacing were markedly attenuated, and the response of individual animals was variable.<h4>Conclusions</h4>Rodent cardiac pacing mimics important features seen in humans. This model may be developed as a simple new tool to study the pathophysiology of ventricular dyssynchrony and CRT.Michal MorWesam MullaSigal ElyagonHovav GabayShani DrorYoram EtzionNoah Liel-CohenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99191 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michal Mor Wesam Mulla Sigal Elyagon Hovav Gabay Shani Dror Yoram Etzion Noah Liel-Cohen Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.
description	<h4>Background</h4>Right ventricular (RV) pacing generates regional disparities in electrical activation and mechanical function (ventricular dyssynchrony). In contrast, left ventricular (LV) or biventricular (BIV) pacing can improve cardiac efficiency in the setting of ventricular dyssynchrony, constituting the rationale for cardiac resynchronization therapy (CRT). Animal models of ventricular dyssynchrony and CRT currently relay on large mammals which are expensive and not readily available to most researchers. We developed a methodology for double-site epicardial pacing in conscious rats. Here, following post-operative recovery, we compared the effects of various pacing modes on LV dyssynchrony in normal rats and in rats with ischemic cardiomyopathy.<h4>Methods</h4>Two bipolar electrodes were implanted in rats as follows: Group A (n = 6) right atrial (RA) and RV sites; Group B (n = 7) RV and LV sites; Group C (n = 8) as in group B in combination with left coronary artery ligation. Electrodes were exteriorized through the back. Following post-operative recovery, two-dimensional transthoracic echocardiography was performed during pacing through the different electrodes. Segmental systolic circumferential strain (Ecc) was used to evaluate LV dyssynchrony.<h4>Results</h4>In normal rats, RV pacing induced marked LV dyssynchrony compared to RA pacing or sinus rhythm, as measured by the standard deviation (SD) of segmental time to peak Ecc, SD of peak Ecc, and the average delay between opposing ventricular segments. LV pacing and, to a greater extend BIV pacing diminished the LV dyssynchrony compared to RV pacing. In rats with extensive MI, the effects of LV and BIV pacing were markedly attenuated, and the response of individual animals was variable.<h4>Conclusions</h4>Rodent cardiac pacing mimics important features seen in humans. This model may be developed as a simple new tool to study the pathophysiology of ventricular dyssynchrony and CRT.
format	article
author	Michal Mor Wesam Mulla Sigal Elyagon Hovav Gabay Shani Dror Yoram Etzion Noah Liel-Cohen
author_facet	Michal Mor Wesam Mulla Sigal Elyagon Hovav Gabay Shani Dror Yoram Etzion Noah Liel-Cohen
author_sort	Michal Mor
title	Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.
title_short	Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.
title_full	Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.
title_fullStr	Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.
title_full_unstemmed	Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.
title_sort	speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fb9205fa16a941e6853be97b1cfda2c8
work_keys_str_mv	AT michalmor speckletrackingechocardiographyelucidatestheeffectofpacingsiteonleftventricularsynchronizationinthenormalandinfarctedratmyocardium AT wesammulla speckletrackingechocardiographyelucidatestheeffectofpacingsiteonleftventricularsynchronizationinthenormalandinfarctedratmyocardium AT sigalelyagon speckletrackingechocardiographyelucidatestheeffectofpacingsiteonleftventricularsynchronizationinthenormalandinfarctedratmyocardium AT hovavgabay speckletrackingechocardiographyelucidatestheeffectofpacingsiteonleftventricularsynchronizationinthenormalandinfarctedratmyocardium AT shanidror speckletrackingechocardiographyelucidatestheeffectofpacingsiteonleftventricularsynchronizationinthenormalandinfarctedratmyocardium AT yorametzion speckletrackingechocardiographyelucidatestheeffectofpacingsiteonleftventricularsynchronizationinthenormalandinfarctedratmyocardium AT noahlielcohen speckletrackingechocardiographyelucidatestheeffectofpacingsiteonleftventricularsynchronizationinthenormalandinfarctedratmyocardium
_version_	1718422022223036416

Speckle-tracking echocardiography elucidates the effect of pacing site on left ventricular synchronization in the normal and infarcted rat myocardium.

Ejemplares similares