The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts

Abstract Immunosuppressive medications, such as tacrolimus and mycophenolate mofetil, are commonly used for reducing the risk of organ rejection in receipts of allogeneic organ transplant. The optimal dosages of these drugs are required for preventing rejection and avoiding toxicity to receipts. Thi...

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Autores principales:	Jianhai Wang, Keqiu Li, Xiaoning Zhang, Dahong Teng, Mingyan Ju, Yaqing Jing, Yuxia Zhao, Guang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb960af1b88c4543a3d51f5ab8142f23
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spelling	oai:doaj.org-article:fb960af1b88c4543a3d51f5ab8142f232021-12-02T12:32:14ZThe correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts10.1038/s41598-017-02698-w2045-2322https://doaj.org/article/fb960af1b88c4543a3d51f5ab8142f232017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02698-whttps://doaj.org/toc/2045-2322Abstract Immunosuppressive medications, such as tacrolimus and mycophenolate mofetil, are commonly used for reducing the risk of organ rejection in receipts of allogeneic organ transplant. The optimal dosages of these drugs are required for preventing rejection and avoiding toxicity to receipts. This study aimed to identify the correlation between the expression profiling of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts. Sixty-four liver transplant receipts were enrolled in this retrospective study. Receipts were divided into low (2–5.9 ng/ml) and high (6–15 ng/ml) tacrolimus groups. Clinical assessment showed that the blood level of tacrolimus was inversely correlated with the liver function evaluated by blood levels of total bilirubin and creatinine. Compared to the high tacrolimus group, expression levels of six cytochrome P450 enzymes, CYP1A1, CYP2B6, CYP3A5, CYP4A11, CYP19A1, and CYP17A1 were significantly higher in the low tacrolimus group. The expression levels of these genes were negatively correlated with the tacrolimus blood level. Enzyme assays showed that CYP3A5 and CYP17A1 exerted direct metabolic effects on tacrolimus and mycophenolate mofetil, respectively. These results support clinical application of this expression profiling of genes in drug metabolism for selection of immunosuppressive medications and optimal dosages for organ transplant receipts.Jianhai WangKeqiu LiXiaoning ZhangDahong TengMingyan JuYaqing JingYuxia ZhaoGuang LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianhai Wang Keqiu Li Xiaoning Zhang Dahong Teng Mingyan Ju Yaqing Jing Yuxia Zhao Guang Li The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts
description	Abstract Immunosuppressive medications, such as tacrolimus and mycophenolate mofetil, are commonly used for reducing the risk of organ rejection in receipts of allogeneic organ transplant. The optimal dosages of these drugs are required for preventing rejection and avoiding toxicity to receipts. This study aimed to identify the correlation between the expression profiling of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts. Sixty-four liver transplant receipts were enrolled in this retrospective study. Receipts were divided into low (2–5.9 ng/ml) and high (6–15 ng/ml) tacrolimus groups. Clinical assessment showed that the blood level of tacrolimus was inversely correlated with the liver function evaluated by blood levels of total bilirubin and creatinine. Compared to the high tacrolimus group, expression levels of six cytochrome P450 enzymes, CYP1A1, CYP2B6, CYP3A5, CYP4A11, CYP19A1, and CYP17A1 were significantly higher in the low tacrolimus group. The expression levels of these genes were negatively correlated with the tacrolimus blood level. Enzyme assays showed that CYP3A5 and CYP17A1 exerted direct metabolic effects on tacrolimus and mycophenolate mofetil, respectively. These results support clinical application of this expression profiling of genes in drug metabolism for selection of immunosuppressive medications and optimal dosages for organ transplant receipts.
format	article
author	Jianhai Wang Keqiu Li Xiaoning Zhang Dahong Teng Mingyan Ju Yaqing Jing Yuxia Zhao Guang Li
author_facet	Jianhai Wang Keqiu Li Xiaoning Zhang Dahong Teng Mingyan Ju Yaqing Jing Yuxia Zhao Guang Li
author_sort	Jianhai Wang
title	The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts
title_short	The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts
title_full	The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts
title_fullStr	The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts
title_full_unstemmed	The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts
title_sort	correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fb960af1b88c4543a3d51f5ab8142f23
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The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts

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