Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex

Abstract The infralimbic cortex (IL) is known to facilitate the formation of extinction memory through reciprocal interactions with the amygdala, which produces fear responses such as freezing. Thus, whether presynaptic input from the amygdala and post-synaptic output of IL neurons are functionally...

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Autores principales:	Jiso Hong, Daesoo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb98ad117881449991b7973afa53a55f
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spelling	oai:doaj.org-article:fb98ad117881449991b7973afa53a55f2021-12-02T11:52:15ZFreezing response-independent facilitation of fear extinction memory in the prefrontal cortex10.1038/s41598-017-04335-y2045-2322https://doaj.org/article/fb98ad117881449991b7973afa53a55f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04335-yhttps://doaj.org/toc/2045-2322Abstract The infralimbic cortex (IL) is known to facilitate the formation of extinction memory through reciprocal interactions with the amygdala, which produces fear responses such as freezing. Thus, whether presynaptic input from the amygdala and post-synaptic output of IL neurons are functionally dissociated in extinction memory formation remains unclear. Here, we demonstrated that photostimulation of IL inputs from BLA did not change freezing responses to conditioned stimuli (CS) during training, but did facilitate extinction memory, measured as a reduction in freezing responses to the CS 1 day later. On the other hand, photostimulation of somata of IL neurons induced an immediate reduction in freezing to CS, but this did not affect extinction memory tested the next day. These results provide in vivo evidence for IL-dependent facilitation of extinction memory without post-synaptic modulation of freezing circuits.Jiso HongDaesoo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiso Hong Daesoo Kim Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex
description	Abstract The infralimbic cortex (IL) is known to facilitate the formation of extinction memory through reciprocal interactions with the amygdala, which produces fear responses such as freezing. Thus, whether presynaptic input from the amygdala and post-synaptic output of IL neurons are functionally dissociated in extinction memory formation remains unclear. Here, we demonstrated that photostimulation of IL inputs from BLA did not change freezing responses to conditioned stimuli (CS) during training, but did facilitate extinction memory, measured as a reduction in freezing responses to the CS 1 day later. On the other hand, photostimulation of somata of IL neurons induced an immediate reduction in freezing to CS, but this did not affect extinction memory tested the next day. These results provide in vivo evidence for IL-dependent facilitation of extinction memory without post-synaptic modulation of freezing circuits.
format	article
author	Jiso Hong Daesoo Kim
author_facet	Jiso Hong Daesoo Kim
author_sort	Jiso Hong
title	Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex
title_short	Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex
title_full	Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex
title_fullStr	Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex
title_full_unstemmed	Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex
title_sort	freezing response-independent facilitation of fear extinction memory in the prefrontal cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fb98ad117881449991b7973afa53a55f
work_keys_str_mv	AT jisohong freezingresponseindependentfacilitationoffearextinctionmemoryintheprefrontalcortex AT daesookim freezingresponseindependentfacilitationoffearextinctionmemoryintheprefrontalcortex
_version_	1718395142028656640

Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex

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