Atonal homolog 1 is a tumor suppressor gene.
Colon cancer accounts for more than 10% of all cancer deaths annually. Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal group of proneural basic helix-loop-helix tran...
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2009
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oai:doaj.org-article:fb9b56ff2e344a0b8af06bba6b4c590a2021-11-25T05:33:47ZAtonal homolog 1 is a tumor suppressor gene.1544-91731545-788510.1371/journal.pbio.1000039https://doaj.org/article/fb9b56ff2e344a0b8af06bba6b4c590a2009-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19243219/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Colon cancer accounts for more than 10% of all cancer deaths annually. Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal group of proneural basic helix-loop-helix transcription factors. We asked whether mouse Atoh1 and human ATOH1 act as tumor suppressor genes in vivo. Genetic knockouts in mouse and molecular analyses in the mouse and in human cancer cell lines support a tumor suppressor function for ATOH1. ATOH1 antagonizes tumor formation and growth by regulating proliferation and apoptosis, likely via activation of the Jun N-terminal kinase signaling pathway. Furthermore, colorectal cancer and Merkel cell carcinoma patients show genetic and epigenetic ATOH1 loss-of-function mutations. Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation.Wouter BossuytAvedis KazanjianNatalie De GeestSofie Van KelstGert De HertoghKarel GeboesGreg P BoivinJudith LucianiFrancois FuksMarinee ChuahThierry VandenDriesschePeter MarynenJan CoolsNoah F ShroyerBassem A HassanPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 2, p e39 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Wouter Bossuyt Avedis Kazanjian Natalie De Geest Sofie Van Kelst Gert De Hertogh Karel Geboes Greg P Boivin Judith Luciani Francois Fuks Marinee Chuah Thierry VandenDriessche Peter Marynen Jan Cools Noah F Shroyer Bassem A Hassan Atonal homolog 1 is a tumor suppressor gene. |
| description |
Colon cancer accounts for more than 10% of all cancer deaths annually. Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal group of proneural basic helix-loop-helix transcription factors. We asked whether mouse Atoh1 and human ATOH1 act as tumor suppressor genes in vivo. Genetic knockouts in mouse and molecular analyses in the mouse and in human cancer cell lines support a tumor suppressor function for ATOH1. ATOH1 antagonizes tumor formation and growth by regulating proliferation and apoptosis, likely via activation of the Jun N-terminal kinase signaling pathway. Furthermore, colorectal cancer and Merkel cell carcinoma patients show genetic and epigenetic ATOH1 loss-of-function mutations. Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation. |
| format |
article |
| author |
Wouter Bossuyt Avedis Kazanjian Natalie De Geest Sofie Van Kelst Gert De Hertogh Karel Geboes Greg P Boivin Judith Luciani Francois Fuks Marinee Chuah Thierry VandenDriessche Peter Marynen Jan Cools Noah F Shroyer Bassem A Hassan |
| author_facet |
Wouter Bossuyt Avedis Kazanjian Natalie De Geest Sofie Van Kelst Gert De Hertogh Karel Geboes Greg P Boivin Judith Luciani Francois Fuks Marinee Chuah Thierry VandenDriessche Peter Marynen Jan Cools Noah F Shroyer Bassem A Hassan |
| author_sort |
Wouter Bossuyt |
| title |
Atonal homolog 1 is a tumor suppressor gene. |
| title_short |
Atonal homolog 1 is a tumor suppressor gene. |
| title_full |
Atonal homolog 1 is a tumor suppressor gene. |
| title_fullStr |
Atonal homolog 1 is a tumor suppressor gene. |
| title_full_unstemmed |
Atonal homolog 1 is a tumor suppressor gene. |
| title_sort |
atonal homolog 1 is a tumor suppressor gene. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2009 |
| url |
https://doaj.org/article/fb9b56ff2e344a0b8af06bba6b4c590a |
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