The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

Abstract HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (ESCRTs). However, the molecular mechanisms that ena...

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Autores principales: Deepankar Gahloth, Graham Heaven, Thomas A. Jowitt, A. Paul Mould, Jordi Bella, Clair Baldock, Philip Woodman, Lydia Tabernero
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fb9b761d30ea4a3cbb093b0b72f678dd
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