Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

Large-scale screens on whole animals could facilitate drug discovery, but are technically challenging. Here, Mondal et al. develop a microfluidic chip combined with an automated imaging platform that enables high-throughput, high-resolution screening of Caenorhabditis elegansdisease models.

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Detalles Bibliográficos
Autores principales: Sudip Mondal, Evan Hegarty, Chris Martin, Sertan Kutal Gökçe, Navid Ghorashian, Adela Ben-Yakar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/fb9f688d911247dcaf6d81fdab681dad
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Sumario:Large-scale screens on whole animals could facilitate drug discovery, but are technically challenging. Here, Mondal et al. develop a microfluidic chip combined with an automated imaging platform that enables high-throughput, high-resolution screening of Caenorhabditis elegansdisease models.