Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

Large-scale screens on whole animals could facilitate drug discovery, but are technically challenging. Here, Mondal et al. develop a microfluidic chip combined with an automated imaging platform that enables high-throughput, high-resolution screening of Caenorhabditis elegansdisease models.

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Autores principales:	Sudip Mondal, Evan Hegarty, Chris Martin, Sertan Kutal Gökçe, Navid Ghorashian, Adela Ben-Yakar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb9f688d911247dcaf6d81fdab681dad
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spelling	oai:doaj.org-article:fb9f688d911247dcaf6d81fdab681dad2021-12-02T16:58:23ZLarge-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model10.1038/ncomms130232041-1723https://doaj.org/article/fb9f688d911247dcaf6d81fdab681dad2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13023https://doaj.org/toc/2041-1723Large-scale screens on whole animals could facilitate drug discovery, but are technically challenging. Here, Mondal et al. develop a microfluidic chip combined with an automated imaging platform that enables high-throughput, high-resolution screening of Caenorhabditis elegansdisease models.Sudip MondalEvan HegartyChris MartinSertan Kutal GökçeNavid GhorashianAdela Ben-YakarNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sudip Mondal Evan Hegarty Chris Martin Sertan Kutal Gökçe Navid Ghorashian Adela Ben-Yakar Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model
description	Large-scale screens on whole animals could facilitate drug discovery, but are technically challenging. Here, Mondal et al. develop a microfluidic chip combined with an automated imaging platform that enables high-throughput, high-resolution screening of Caenorhabditis elegansdisease models.
format	article
author	Sudip Mondal Evan Hegarty Chris Martin Sertan Kutal Gökçe Navid Ghorashian Adela Ben-Yakar
author_facet	Sudip Mondal Evan Hegarty Chris Martin Sertan Kutal Gökçe Navid Ghorashian Adela Ben-Yakar
author_sort	Sudip Mondal
title	Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model
title_short	Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model
title_full	Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model
title_fullStr	Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model
title_full_unstemmed	Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model
title_sort	large-scale microfluidics providing high-resolution and high-throughput screening of caenorhabditis elegans poly-glutamine aggregation model
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fb9f688d911247dcaf6d81fdab681dad
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Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

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