Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

The autophagy adapter p62/SQSTM1 plays a key role in selective autophagy and also recognizes N-end rule substrates. Here the authors provide molecular insights into p62 N-end rule substrate recognition by solving the structures of the p62 ZZ-domain in complex with various type 1 and type 2 degrons a...

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Autores principales:	Do Hoon Kwon, Ok Hyun Park, Leehyeon Kim, Yang Ouk Jung, Yeonkyoung Park, Hyeongseop Jeong, Jaekyung Hyun, Yoon Ki Kim, Hyun Kyu Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb9f90376e734fe7b3892591b7d6608f
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spelling	oai:doaj.org-article:fb9f90376e734fe7b3892591b7d6608f2021-12-02T16:56:54ZInsights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter10.1038/s41467-018-05825-x2041-1723https://doaj.org/article/fb9f90376e734fe7b3892591b7d6608f2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05825-xhttps://doaj.org/toc/2041-1723The autophagy adapter p62/SQSTM1 plays a key role in selective autophagy and also recognizes N-end rule substrates. Here the authors provide molecular insights into p62 N-end rule substrate recognition by solving the structures of the p62 ZZ-domain in complex with various type 1 and type 2 degrons and also show the pH dependent oligomerization of p62.Do Hoon KwonOk Hyun ParkLeehyeon KimYang Ouk JungYeonkyoung ParkHyeongseop JeongJaekyung HyunYoon Ki KimHyun Kyu SongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Do Hoon Kwon Ok Hyun Park Leehyeon Kim Yang Ouk Jung Yeonkyoung Park Hyeongseop Jeong Jaekyung Hyun Yoon Ki Kim Hyun Kyu Song Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
description	The autophagy adapter p62/SQSTM1 plays a key role in selective autophagy and also recognizes N-end rule substrates. Here the authors provide molecular insights into p62 N-end rule substrate recognition by solving the structures of the p62 ZZ-domain in complex with various type 1 and type 2 degrons and also show the pH dependent oligomerization of p62.
format	article
author	Do Hoon Kwon Ok Hyun Park Leehyeon Kim Yang Ouk Jung Yeonkyoung Park Hyeongseop Jeong Jaekyung Hyun Yoon Ki Kim Hyun Kyu Song
author_facet	Do Hoon Kwon Ok Hyun Park Leehyeon Kim Yang Ouk Jung Yeonkyoung Park Hyeongseop Jeong Jaekyung Hyun Yoon Ki Kim Hyun Kyu Song
author_sort	Do Hoon Kwon
title	Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
title_short	Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
title_full	Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
title_fullStr	Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
title_full_unstemmed	Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
title_sort	insights into degradation mechanism of n-end rule substrates by p62/sqstm1 autophagy adapter
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb9f90376e734fe7b3892591b7d6608f
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Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

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