Carbapenemases as factors of Resistance to Antibacterial Drugs

Antibiotic drugs are used to treat and prevent bacterial infections around the world. The emergence and spread of bacterial resistance to carbapenems is currently a real threat that determines the need for its timely detection and suppression. Carbapenem-resistant Enterobacteriaceae, Pseudomonas a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	A. V. Nevezhina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	carbapenemase beta-lactamase antibiotic Science Q
Acceso en línea:	https://doaj.org/article/fba17456b56f4fb698b8ecb470d259b9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fba17456b56f4fb698b8ecb470d259b9
record_format	dspace
spelling	oai:doaj.org-article:fba17456b56f4fb698b8ecb470d259b92021-11-23T06:14:45ZCarbapenemases as factors of Resistance to Antibacterial Drugs2541-94202587-959610.29413/ABS.2020-5.6.11https://doaj.org/article/fba17456b56f4fb698b8ecb470d259b92021-01-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2501https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Antibiotic drugs are used to treat and prevent bacterial infections around the world. The emergence and spread of bacterial resistance to carbapenems is currently a real threat that determines the need for its timely detection and suppression. Carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii are ranked as the highest priority in the 2017 WHO Global Priority Pathogens List. The number of known carbapenemases is constantly increasing, but the most common are IMP-type, VIM-type, NDM-type, KPC-type, and OXA-type. Carbapenemases belong to molecular class B (metallo-β-lactamases) or molecular classes A and D (serine carbapenemases). The genes encoding carbapenemases are part of the mobile genetic elements, which contributes to their rapid intra- and interspecific transfer. In this regard, the purpose of this review is to get acquainted with the current information on the classification and characteristics of carbapenemases, ways to overcome the spread of resistance to carbapenems. At the same time, the article pays attention not only to infectious agents, but also to those carriers of carbapenemases that have not been seen as infectious agents, since they can also influence the evolution of resistance genes.A. V. NevezhinaScientific Сentre for Family Health and Human Reproduction Problemsarticlecarbapenemasebeta-lactamaseantibioticScienceQRUActa Biomedica Scientifica, Vol 5, Iss 6, Pp 95-105 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	carbapenemase beta-lactamase antibiotic Science Q
spellingShingle	carbapenemase beta-lactamase antibiotic Science Q A. V. Nevezhina Carbapenemases as factors of Resistance to Antibacterial Drugs
description	Antibiotic drugs are used to treat and prevent bacterial infections around the world. The emergence and spread of bacterial resistance to carbapenems is currently a real threat that determines the need for its timely detection and suppression. Carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii are ranked as the highest priority in the 2017 WHO Global Priority Pathogens List. The number of known carbapenemases is constantly increasing, but the most common are IMP-type, VIM-type, NDM-type, KPC-type, and OXA-type. Carbapenemases belong to molecular class B (metallo-β-lactamases) or molecular classes A and D (serine carbapenemases). The genes encoding carbapenemases are part of the mobile genetic elements, which contributes to their rapid intra- and interspecific transfer. In this regard, the purpose of this review is to get acquainted with the current information on the classification and characteristics of carbapenemases, ways to overcome the spread of resistance to carbapenems. At the same time, the article pays attention not only to infectious agents, but also to those carriers of carbapenemases that have not been seen as infectious agents, since they can also influence the evolution of resistance genes.
format	article
author	A. V. Nevezhina
author_facet	A. V. Nevezhina
author_sort	A. V. Nevezhina
title	Carbapenemases as factors of Resistance to Antibacterial Drugs
title_short	Carbapenemases as factors of Resistance to Antibacterial Drugs
title_full	Carbapenemases as factors of Resistance to Antibacterial Drugs
title_fullStr	Carbapenemases as factors of Resistance to Antibacterial Drugs
title_full_unstemmed	Carbapenemases as factors of Resistance to Antibacterial Drugs
title_sort	carbapenemases as factors of resistance to antibacterial drugs
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/fba17456b56f4fb698b8ecb470d259b9
work_keys_str_mv	AT avnevezhina carbapenemasesasfactorsofresistancetoantibacterialdrugs
_version_	1718416922680229888

Carbapenemases as factors of Resistance to Antibacterial Drugs

Ejemplares similares