ZEB1 protects skeletal muscle from damage and is required for its regeneration

Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiesc...

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Main Authors:	Laura Siles, Chiara Ninfali, Marlies Cortés, Douglas S. Darling, Antonio Postigo
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/fba352a7d17a4354bb83f498fd54b6a6
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spelling	oai:doaj.org-article:fba352a7d17a4354bb83f498fd54b6a62021-12-02T15:35:47ZZEB1 protects skeletal muscle from damage and is required for its regeneration10.1038/s41467-019-08983-82041-1723https://doaj.org/article/fba352a7d17a4354bb83f498fd54b6a62019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08983-8https://doaj.org/toc/2041-1723Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.Laura SilesChiara NinfaliMarlies CortésDouglas S. DarlingAntonio PostigoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Siles Chiara Ninfali Marlies Cortés Douglas S. Darling Antonio Postigo ZEB1 protects skeletal muscle from damage and is required for its regeneration
description	Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.
format	article
author	Laura Siles Chiara Ninfali Marlies Cortés Douglas S. Darling Antonio Postigo
author_facet	Laura Siles Chiara Ninfali Marlies Cortés Douglas S. Darling Antonio Postigo
author_sort	Laura Siles
title	ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_short	ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_full	ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_fullStr	ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_full_unstemmed	ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_sort	zeb1 protects skeletal muscle from damage and is required for its regeneration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fba352a7d17a4354bb83f498fd54b6a6
work_keys_str_mv	AT laurasiles zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration AT chiaraninfali zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration AT marliescortes zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration AT douglassdarling zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration AT antoniopostigo zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration
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ZEB1 protects skeletal muscle from damage and is required for its regeneration

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