Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells
Our understanding of the hierarchical structure of acute leukemia has yet to be fully translated into therapeutic approaches. Indeed, chemotherapy still has to take into account the possibility that leukemia-initiating cells may have a distinct chemosensitivity profile compared to the bulk of the tu...
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MDPI AG
2021
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oai:doaj.org-article:fba48e79826043c6a263d7d90bb21e712021-11-11T15:33:47ZOncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells10.3390/cancers132155112072-6694https://doaj.org/article/fba48e79826043c6a263d7d90bb21e712021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5511https://doaj.org/toc/2072-6694Our understanding of the hierarchical structure of acute leukemia has yet to be fully translated into therapeutic approaches. Indeed, chemotherapy still has to take into account the possibility that leukemia-initiating cells may have a distinct chemosensitivity profile compared to the bulk of the tumor, and therefore are spared by the current treatment, causing the relapse of the disease. Therefore, the identification of the cell-of-origin of leukemia remains a longstanding question and an exciting challenge in cancer research of the last few decades. With a particular focus on acute lymphoblastic leukemia, we present in this review the previous and current concepts exploring the phenotypic, genetic and functional heterogeneity in patients. We also discuss the benefits of using engineered mouse models to explore the early steps of leukemia development and to identify the biological mechanisms driving the emergence of leukemia-initiating cells. Finally, we describe the major prospects for the discovery of new therapeutic strategies that specifically target their aberrant stem cell-like functions.Vincent FregonaManon BayetBastien GerbyMDPI AGarticleoncogene-induced reprogramming(pre-)leukemic stem cellscell plasticityself-renewaloncogenic transcription factorsacute lymphoblastic leukemiaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5511, p 5511 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
oncogene-induced reprogramming (pre-)leukemic stem cells cell plasticity self-renewal oncogenic transcription factors acute lymphoblastic leukemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
oncogene-induced reprogramming (pre-)leukemic stem cells cell plasticity self-renewal oncogenic transcription factors acute lymphoblastic leukemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Vincent Fregona Manon Bayet Bastien Gerby Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells |
| description |
Our understanding of the hierarchical structure of acute leukemia has yet to be fully translated into therapeutic approaches. Indeed, chemotherapy still has to take into account the possibility that leukemia-initiating cells may have a distinct chemosensitivity profile compared to the bulk of the tumor, and therefore are spared by the current treatment, causing the relapse of the disease. Therefore, the identification of the cell-of-origin of leukemia remains a longstanding question and an exciting challenge in cancer research of the last few decades. With a particular focus on acute lymphoblastic leukemia, we present in this review the previous and current concepts exploring the phenotypic, genetic and functional heterogeneity in patients. We also discuss the benefits of using engineered mouse models to explore the early steps of leukemia development and to identify the biological mechanisms driving the emergence of leukemia-initiating cells. Finally, we describe the major prospects for the discovery of new therapeutic strategies that specifically target their aberrant stem cell-like functions. |
| format |
article |
| author |
Vincent Fregona Manon Bayet Bastien Gerby |
| author_facet |
Vincent Fregona Manon Bayet Bastien Gerby |
| author_sort |
Vincent Fregona |
| title |
Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells |
| title_short |
Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells |
| title_full |
Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells |
| title_fullStr |
Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells |
| title_full_unstemmed |
Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells |
| title_sort |
oncogene-induced reprogramming in acute lymphoblastic leukemia: towards targeted therapy of leukemia-initiating cells |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/fba48e79826043c6a263d7d90bb21e71 |
| work_keys_str_mv |
AT vincentfregona oncogeneinducedreprogramminginacutelymphoblasticleukemiatowardstargetedtherapyofleukemiainitiatingcells AT manonbayet oncogeneinducedreprogramminginacutelymphoblasticleukemiatowardstargetedtherapyofleukemiainitiatingcells AT bastiengerby oncogeneinducedreprogramminginacutelymphoblasticleukemiatowardstargetedtherapyofleukemiainitiatingcells |
| _version_ |
1718435220334575616 |