Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.

Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.

The major DNA repair pathways operate on damage in double-strand DNA because they use the intact strand as a template after damage removal. Therefore, lesions in transient single-strand stretches of chromosomal DNA are expected to be especially threatening to genome stability. To test this hypothesi...

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Detalles Bibliográficos
Autores principales: Yong Yang, Joan Sterling, Francesca Storici, Michael A Resnick, Dmitry A Gordenin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/fba5064b3f7f427dad3cfef0c0f474c7
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