Galectin-3 as a prognostic biomarker for diabetic nephropathy

Hossam Hodeib,1 Maha M Hagras,1 Dina Abdelhai,1 Mona M Watany,1 Amal Selim,2 Mohamed A Tawfik,2 Mohamed A Elsebaey,2 Samah A Elshweikh2 1Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt Introdu...

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Autores principales:	Hodeib H, Hagras MM, Abdelhai D, Watany MM, Selim A, Tawfik MA, Elsebaey MA, Elshweikh SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Diabetic nephropathy galectin-3 albumin/ creatinine ratio. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/fba9ff6832c54d028c4f295075329407
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spelling	oai:doaj.org-article:fba9ff6832c54d028c4f2950753294072021-12-02T09:06:39ZGalectin-3 as a prognostic biomarker for diabetic nephropathy1178-7007https://doaj.org/article/fba9ff6832c54d028c4f2950753294072019-03-01T00:00:00Zhttps://www.dovepress.com/galectin-3-as-a-prognostic-biomarker-for-diabetic-nephropathy-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Hossam Hodeib,1 Maha M Hagras,1 Dina Abdelhai,1 Mona M Watany,1 Amal Selim,2 Mohamed A Tawfik,2 Mohamed A Elsebaey,2 Samah A Elshweikh2 1Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt Introduction: Diabetic nephropathy (DN) represents one of the main causes of end-stage renal disease in type 2 diabetes mellitus (DM) patients. Galectin-3 has been implicated in pathogenesis of many pathological conditions. To date, there are limited data regarding the relationship between galectin-3 and DN.  Aim of the study: Evaluation of serum galectin-3 as a novel prognostic biomarker in patients with DN.  Patients and methods: This prospective study was carried out in the Internal Medicine and Clinical Pathology Departments, Tanta University Hospital, Egypt, from March 2015 to March 2018 on 300 patients with type 2 DM. Patients were divided into three groups: group I included 100 patients with albumin/creatinine ratio (ACR) 300 mg/g (macroalbuminuria). All patients were subjected to the following: full history taking, clinical examination, and laboratory evaluation (HbA1c, creatinine, estimated glomerular filtration rate, ACR, and serum galectin-3). Results: The mean levels of galectin-3 were significantly higher in patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria. Galectin-3 was a significant predictor for progression to microalbuminuria, macroalbuminuria, dialysis, and death among patients with type 2 DM. Conclusion: Based on this single center prospective study, serum galectin-3 is considered a significant predictor for DN progression among patients with type 2 DM. Keywords: diabetic nephropathy, galectin-3, albumin/creatinine ratio, microalbuminuria, macroalbuminuria, dialysis, diabetes mellitusHodeib HHagras MMAbdelhai DWatany MMSelim ATawfik MAElsebaey MAElshweikh SADove Medical PressarticleDiabetic nephropathygalectin-3albumin/ creatinine ratio.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 325-331 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetic nephropathy galectin-3 albumin/ creatinine ratio. Specialties of internal medicine RC581-951
spellingShingle	Diabetic nephropathy galectin-3 albumin/ creatinine ratio. Specialties of internal medicine RC581-951 Hodeib H Hagras MM Abdelhai D Watany MM Selim A Tawfik MA Elsebaey MA Elshweikh SA Galectin-3 as a prognostic biomarker for diabetic nephropathy
description	Hossam Hodeib,1 Maha M Hagras,1 Dina Abdelhai,1 Mona M Watany,1 Amal Selim,2 Mohamed A Tawfik,2 Mohamed A Elsebaey,2 Samah A Elshweikh2 1Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt Introduction: Diabetic nephropathy (DN) represents one of the main causes of end-stage renal disease in type 2 diabetes mellitus (DM) patients. Galectin-3 has been implicated in pathogenesis of many pathological conditions. To date, there are limited data regarding the relationship between galectin-3 and DN.  Aim of the study: Evaluation of serum galectin-3 as a novel prognostic biomarker in patients with DN.  Patients and methods: This prospective study was carried out in the Internal Medicine and Clinical Pathology Departments, Tanta University Hospital, Egypt, from March 2015 to March 2018 on 300 patients with type 2 DM. Patients were divided into three groups: group I included 100 patients with albumin/creatinine ratio (ACR) 300 mg/g (macroalbuminuria). All patients were subjected to the following: full history taking, clinical examination, and laboratory evaluation (HbA1c, creatinine, estimated glomerular filtration rate, ACR, and serum galectin-3). Results: The mean levels of galectin-3 were significantly higher in patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria. Galectin-3 was a significant predictor for progression to microalbuminuria, macroalbuminuria, dialysis, and death among patients with type 2 DM. Conclusion: Based on this single center prospective study, serum galectin-3 is considered a significant predictor for DN progression among patients with type 2 DM. Keywords: diabetic nephropathy, galectin-3, albumin/creatinine ratio, microalbuminuria, macroalbuminuria, dialysis, diabetes mellitus
format	article
author	Hodeib H Hagras MM Abdelhai D Watany MM Selim A Tawfik MA Elsebaey MA Elshweikh SA
author_facet	Hodeib H Hagras MM Abdelhai D Watany MM Selim A Tawfik MA Elsebaey MA Elshweikh SA
author_sort	Hodeib H
title	Galectin-3 as a prognostic biomarker for diabetic nephropathy
title_short	Galectin-3 as a prognostic biomarker for diabetic nephropathy
title_full	Galectin-3 as a prognostic biomarker for diabetic nephropathy
title_fullStr	Galectin-3 as a prognostic biomarker for diabetic nephropathy
title_full_unstemmed	Galectin-3 as a prognostic biomarker for diabetic nephropathy
title_sort	galectin-3 as a prognostic biomarker for diabetic nephropathy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/fba9ff6832c54d028c4f295075329407
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Galectin-3 as a prognostic biomarker for diabetic nephropathy

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