Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia

Jun Yang,1 Yonghong Dai,1 Zuowen Zhang,2 Yue Chen3 1Department of Critical Care Medicine, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of China; 2Department of Neurology, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of C...

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Autores principales:	Yang J, Dai Y, Zhang Z, Chen Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	stroke-associated pneumonia a2ds2 score interleukin 6 multivariate analysis receiver operating characteristic curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fbae14465f11480192a117867d1c1c5b
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spelling	oai:doaj.org-article:fbae14465f11480192a117867d1c1c5b2021-12-02T13:02:59ZValue of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia1178-2021https://doaj.org/article/fbae14465f11480192a117867d1c1c5b2020-10-01T00:00:00Zhttps://www.dovepress.com/value-of-combination-of-the-a2ds2-score-and-il-6-in-predicting-stroke--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jun Yang,1 Yonghong Dai,1 Zuowen Zhang,2 Yue Chen3 1Department of Critical Care Medicine, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of China; 2Department of Neurology, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of China; 3Department of Rehabilitation, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of ChinaCorrespondence: Yue ChenDepartment of Rehabilitation, Central Hospital of Jiangjin District, Chongqing Dingshan Street, Jiangjin District, Chongqing 402260, People’s Republic of ChinaTel +86-15823491696Email wenlinlin0606@163.comPurpose: To evaluate the value of the combination of the age, atrial fibrillation, dysphagia, male sex, and National Institutes of Health Stroke Scale (A2DS2) score and serum interleukin 6 (IL-6) concentration in predicting stroke-associated pneumonia (SAP).Patients and Methods: A total of 398 patients with acute ischemic stroke (AIS) from the medical ward was included in this retrospective study. They were divided into the SAP group and non-SAP group according to the diagnostic criteria of SAP. Multivariate analysis was performed to analyze the association between the A2DS2 score, serum IL-6 concentration, and SAP using a backward stepwise logistic regression model. The receiver operating characteristic (ROC) curve was used to evaluate the value of the A2DS2 score, serum IL-6 concentration and combination of A2DS2 score and IL-6 in predicting SAP.Results: SAP was diagnosed in 70 patients (17.6%). Multivariate analysis showed that the A2DS2 score (odds ratio [OR]: 2.25, 95% confidence interval [CI]: 1.17– 4.99, P=0.017) and serum IL-6 concentration (OR: 1.76, 95% CI: 1.44– 1.95, P< 0.001) was independently associated with SAP after adjusting for age, smoking, hypertension, hyperlipidemia, and atrial fibrillation. When the A2DS2 score, serum IL-6 concentration and combination of A2DS2 score and IL-6 were employed to predict SAP, the AUC was 0.824 (SE: 0.026, 95% CI: 0.773– 0.875), 0.715 (SE: 0.034, 95% CI: 0.641– 0.788) and 0.917 (SE: 0.015, 95% CI: 0.887– 0.946), respectively. The AUC of combinative prediction was significantly higher than independent prediction (0.917 vs. 0.824, Z=3.098, P< 0.001; 0.917 vs. 0.715, Z=5.436, P< 0.001).Conclusion: The addition of serum IL-6 to the A2DS2 score could significantly enhance the AUC of predicting SAP in AIS patients from the medical ward.Keywords: stroke-associated pneumonia; SAP, A2DS2 score, interleukin 6, multivariate analysis, receiver operating characteristic curve; ROCYang JDai YZhang ZChen YDove Medical Pressarticlestroke-associated pneumoniaa2ds2 scoreinterleukin 6multivariate analysisreceiver operating characteristic curveNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2353-2359 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke-associated pneumonia a2ds2 score interleukin 6 multivariate analysis receiver operating characteristic curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	stroke-associated pneumonia a2ds2 score interleukin 6 multivariate analysis receiver operating characteristic curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yang J Dai Y Zhang Z Chen Y Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia
description	Jun Yang,1 Yonghong Dai,1 Zuowen Zhang,2 Yue Chen3 1Department of Critical Care Medicine, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of China; 2Department of Neurology, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of China; 3Department of Rehabilitation, Central Hospital of Jiangjin District, Chongqing 402260, People’s Republic of ChinaCorrespondence: Yue ChenDepartment of Rehabilitation, Central Hospital of Jiangjin District, Chongqing Dingshan Street, Jiangjin District, Chongqing 402260, People’s Republic of ChinaTel +86-15823491696Email wenlinlin0606@163.comPurpose: To evaluate the value of the combination of the age, atrial fibrillation, dysphagia, male sex, and National Institutes of Health Stroke Scale (A2DS2) score and serum interleukin 6 (IL-6) concentration in predicting stroke-associated pneumonia (SAP).Patients and Methods: A total of 398 patients with acute ischemic stroke (AIS) from the medical ward was included in this retrospective study. They were divided into the SAP group and non-SAP group according to the diagnostic criteria of SAP. Multivariate analysis was performed to analyze the association between the A2DS2 score, serum IL-6 concentration, and SAP using a backward stepwise logistic regression model. The receiver operating characteristic (ROC) curve was used to evaluate the value of the A2DS2 score, serum IL-6 concentration and combination of A2DS2 score and IL-6 in predicting SAP.Results: SAP was diagnosed in 70 patients (17.6%). Multivariate analysis showed that the A2DS2 score (odds ratio [OR]: 2.25, 95% confidence interval [CI]: 1.17– 4.99, P=0.017) and serum IL-6 concentration (OR: 1.76, 95% CI: 1.44– 1.95, P< 0.001) was independently associated with SAP after adjusting for age, smoking, hypertension, hyperlipidemia, and atrial fibrillation. When the A2DS2 score, serum IL-6 concentration and combination of A2DS2 score and IL-6 were employed to predict SAP, the AUC was 0.824 (SE: 0.026, 95% CI: 0.773– 0.875), 0.715 (SE: 0.034, 95% CI: 0.641– 0.788) and 0.917 (SE: 0.015, 95% CI: 0.887– 0.946), respectively. The AUC of combinative prediction was significantly higher than independent prediction (0.917 vs. 0.824, Z=3.098, P< 0.001; 0.917 vs. 0.715, Z=5.436, P< 0.001).Conclusion: The addition of serum IL-6 to the A2DS2 score could significantly enhance the AUC of predicting SAP in AIS patients from the medical ward.Keywords: stroke-associated pneumonia; SAP, A2DS2 score, interleukin 6, multivariate analysis, receiver operating characteristic curve; ROC
format	article
author	Yang J Dai Y Zhang Z Chen Y
author_facet	Yang J Dai Y Zhang Z Chen Y
author_sort	Yang J
title	Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia
title_short	Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia
title_full	Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia
title_fullStr	Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia
title_full_unstemmed	Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia
title_sort	value of combination of the a2ds2 score and il-6 in predicting stroke-associated pneumonia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fbae14465f11480192a117867d1c1c5b
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Value of Combination of the A2DS2 Score and IL-6 in Predicting Stroke-Associated Pneumonia

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