In situ slow-release recombinant growth differentiation factor 11 exhibits therapeutic efficacy in ischemic stroke

Systemic growth differentiation factor 11 (GDF11) treatment improves the vasculature in the hippocampus and cortex in mice in recent studies. However, systemic application of recombinant GDF11 (rGDF11) cannot cross the brain blood barrier (BBB). Thus, large doses and long-term administration are req...

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Autores principales: Hsing-Hui Su, Jiin-Cherng Yen, Jiuan-Miaw Liao, Yi-Hsin Wang, Pei-Hsun Liu, Iona J. MacDonald, Chin-Feng Tsai, Yi-Hung Chen, Shiang-Suo Huang
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/fbae608d1ad34d7091790c7bc4032465
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